The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy
Currently one of the factors of allergy predisposition is the increase in barrier permeability of the mucous membranes of the respiratory system and the gastrointestinal tract (GIT). It defines the probability of an emergence of an allergic response. To understand the mechanisms of the interaction o...
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| Format: | Article |
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Siberian State Medical University (Tomsk)
2017-07-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/874 |
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| author | Oksana M. Kurbacheva Miramgul E. Amanturlieva |
| author_facet | Oksana M. Kurbacheva Miramgul E. Amanturlieva |
| author_sort | Oksana M. Kurbacheva |
| collection | DOAJ |
| description | Currently one of the factors of allergy predisposition is the increase in barrier permeability of the mucous membranes of the respiratory system and the gastrointestinal tract (GIT). It defines the probability of an emergence of an allergic response. To understand the mechanisms of the interaction of the mucous membranes of different systems that explain their common function is undoubtedly necessary for discussion of this problem. The features of microbiome influence and the changes of the microbiome state during the formation of the immune response to the contact with allergens are of particular interest. The structure of the epithelial barrier of the airwaysand GIT, and mechanisms of allergen transport through barrier systems with the subsequent interaction with the cells (?) associated with barrier fabrics have been considered. The possible role of the barrier function of mucous membranes in conducting sublingual allergen-specific immunotherapy (SLIT) is discussed. |
| format | Article |
| id | doaj-art-bc5554bc0a1546579fef17f5ce7cb70e |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-bc5554bc0a1546579fef17f5ce7cb70e2025-08-20T03:21:42ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-07-01162324610.20538/1682-0363-2017-2-32-46663The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapyOksana M. Kurbacheva0Miramgul E. Amanturlieva1National Research Center (NRC) Institute of ImmunologyNational Research Center (NRC) Institute of ImmunologyCurrently one of the factors of allergy predisposition is the increase in barrier permeability of the mucous membranes of the respiratory system and the gastrointestinal tract (GIT). It defines the probability of an emergence of an allergic response. To understand the mechanisms of the interaction of the mucous membranes of different systems that explain their common function is undoubtedly necessary for discussion of this problem. The features of microbiome influence and the changes of the microbiome state during the formation of the immune response to the contact with allergens are of particular interest. The structure of the epithelial barrier of the airwaysand GIT, and mechanisms of allergen transport through barrier systems with the subsequent interaction with the cells (?) associated with barrier fabrics have been considered. The possible role of the barrier function of mucous membranes in conducting sublingual allergen-specific immunotherapy (SLIT) is discussed.https://bulletin.ssmu.ru/jour/article/view/874barrier function of mucous membranesallergensmicrobiomesublingual allergenspecific immunotherapyallergic rhinitisbronchial asthmaatopic dermatitis |
| spellingShingle | Oksana M. Kurbacheva Miramgul E. Amanturlieva The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy Бюллетень сибирской медицины barrier function of mucous membranes allergens microbiome sublingual allergen specific immunotherapy allergic rhinitis bronchial asthma atopic dermatitis |
| title | The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy |
| title_full | The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy |
| title_fullStr | The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy |
| title_full_unstemmed | The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy |
| title_short | The role of barrier function of mucous membranes in allergic diseases and sublingual allergen-specific immunotherapy |
| title_sort | role of barrier function of mucous membranes in allergic diseases and sublingual allergen specific immunotherapy |
| topic | barrier function of mucous membranes allergens microbiome sublingual allergen specific immunotherapy allergic rhinitis bronchial asthma atopic dermatitis |
| url | https://bulletin.ssmu.ru/jour/article/view/874 |
| work_keys_str_mv | AT oksanamkurbacheva theroleofbarrierfunctionofmucousmembranesinallergicdiseasesandsublingualallergenspecificimmunotherapy AT miramguleamanturlieva theroleofbarrierfunctionofmucousmembranesinallergicdiseasesandsublingualallergenspecificimmunotherapy AT oksanamkurbacheva roleofbarrierfunctionofmucousmembranesinallergicdiseasesandsublingualallergenspecificimmunotherapy AT miramguleamanturlieva roleofbarrierfunctionofmucousmembranesinallergicdiseasesandsublingualallergenspecificimmunotherapy |