Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals
Background: High-intensity interval training (HIIT) exercise and antioxidant supplements are an alternative to lifestyle modification for reducing oxidative stress and preventing cardiovascular risk factors; however, there remains very limited evidence regarding the potential impacts of combination...
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2025-01-01
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| Series: | Physical Activity and Health |
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| Online Access: | https://account.paahjournal.com/index.php/up-j-pah/article/view/400 |
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| author | Surachat Buddhisa Nattaphol Prakobkaew Piyapong Prasertsri Sudarat Boonpitak Puttipong Poncumhak Orachorn Boonla |
| author_facet | Surachat Buddhisa Nattaphol Prakobkaew Piyapong Prasertsri Sudarat Boonpitak Puttipong Poncumhak Orachorn Boonla |
| author_sort | Surachat Buddhisa |
| collection | DOAJ |
| description | Background: High-intensity interval training (HIIT) exercise and antioxidant supplements are an alternative to lifestyle modification for reducing oxidative stress and preventing cardiovascular risk factors; however, there remains very limited evidence regarding the potential impacts of combination of square stepping HIIT with Phyllanthus amarus (PA) on blood biochemical levels in the overweight and obese individuals. Objectives: This study aimed to investigate the effects of square-stepping HIIT combined with PA supplementation on changes in blood glucose and insulin activity, lipid profile, inflammation, and oxidative stress in overweight and obese individuals. Methods: The number of 48 overweight and obese individuals was divided into 4 groups (n = 12/group) and total 40 participants were completed the 8-week program: 1) control group (n = 8), 2) PA group (n = 12); received PA at 150 mg/day, 5 days/wk, 3) square-stepping HIIT (n = 9); received square-stepping HIIT training for 15 min/day, 3 days/wk, 8 weeks and 4) HIIT+PA group (n = 11). Venous blood was collected for measurements of the glucose, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein concentrations, the serum proinflammatory cytokines interleukin (IL)–6 and anti-inflammatory cytokine IL-10. Also, plasma malondialdehyde (MDA) was determined by measuring thiobarbituric acid reactive substances. Results: HIIT+PA has been a significant decrease in fasting blood glucose and oral glucose tolerance test at 120 min compared to baseline (p = 0.01). Both HIIT and HIIT+PA reduced oxidative stress by indicating a decrease in plasma MDA compared to baseline in overweight and obese individuals (p = 0.032 and p = 0.009, respectively); however, there were no significant differences between the four groups. The data on lipid profiles and inflammatory markers did not show any significant differences in all groups. Conclusion: The square-stepping HIIT combined with PA supplementation improved insulin activity and reduced fasting blood glucose and oxidative stress in overweight and obese individuals. |
| format | Article |
| id | doaj-art-bc551d25f36a4508ad008bc2dc10b6e1 |
| institution | Kabale University |
| issn | 2515-2270 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Physical Activity and Health |
| spelling | doaj-art-bc551d25f36a4508ad008bc2dc10b6e12025-02-11T05:41:44ZengUbiquity PressPhysical Activity and Health2515-22702025-01-019116–2616–2610.5334/paah.400400Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese IndividualsSurachat Buddhisa0https://orcid.org/0000-0002-6605-8980Nattaphol Prakobkaew1https://orcid.org/0000-0002-8981-2480Piyapong Prasertsri2https://orcid.org/0000-0003-2652-4622Sudarat Boonpitak3https://orcid.org/0009-0003-0302-7065Puttipong Poncumhak4https://orcid.org/0000-0002-7788-7151Orachorn Boonla5https://orcid.org/0000-0002-6629-9290Faculty of Allied Health Sciences, Burapha University, ChonburiFaculty of Allied Health Sciences, Burapha University, ChonburiFaculty of Allied Health Sciences, Burapha University, ChonburiFaculty of Allied Health Sciences, Burapha University, ChonburiDepartment of Physical Therapy, School of Allied Health Sciences, University of Phayao, PhayaoFaculty of Allied Health Sciences, Burapha University, ChonburiBackground: High-intensity interval training (HIIT) exercise and antioxidant supplements are an alternative to lifestyle modification for reducing oxidative stress and preventing cardiovascular risk factors; however, there remains very limited evidence regarding the potential impacts of combination of square stepping HIIT with Phyllanthus amarus (PA) on blood biochemical levels in the overweight and obese individuals. Objectives: This study aimed to investigate the effects of square-stepping HIIT combined with PA supplementation on changes in blood glucose and insulin activity, lipid profile, inflammation, and oxidative stress in overweight and obese individuals. Methods: The number of 48 overweight and obese individuals was divided into 4 groups (n = 12/group) and total 40 participants were completed the 8-week program: 1) control group (n = 8), 2) PA group (n = 12); received PA at 150 mg/day, 5 days/wk, 3) square-stepping HIIT (n = 9); received square-stepping HIIT training for 15 min/day, 3 days/wk, 8 weeks and 4) HIIT+PA group (n = 11). Venous blood was collected for measurements of the glucose, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein concentrations, the serum proinflammatory cytokines interleukin (IL)–6 and anti-inflammatory cytokine IL-10. Also, plasma malondialdehyde (MDA) was determined by measuring thiobarbituric acid reactive substances. Results: HIIT+PA has been a significant decrease in fasting blood glucose and oral glucose tolerance test at 120 min compared to baseline (p = 0.01). Both HIIT and HIIT+PA reduced oxidative stress by indicating a decrease in plasma MDA compared to baseline in overweight and obese individuals (p = 0.032 and p = 0.009, respectively); however, there were no significant differences between the four groups. The data on lipid profiles and inflammatory markers did not show any significant differences in all groups. Conclusion: The square-stepping HIIT combined with PA supplementation improved insulin activity and reduced fasting blood glucose and oxidative stress in overweight and obese individuals.https://account.paahjournal.com/index.php/up-j-pah/article/view/400aerobic exercisephysical activityantioxidant supplementoxidative stress |
| spellingShingle | Surachat Buddhisa Nattaphol Prakobkaew Piyapong Prasertsri Sudarat Boonpitak Puttipong Poncumhak Orachorn Boonla Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals Physical Activity and Health aerobic exercise physical activity antioxidant supplement oxidative stress |
| title | Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals |
| title_full | Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals |
| title_fullStr | Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals |
| title_full_unstemmed | Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals |
| title_short | Square-Stepping HIIT Combined With 'Phyllanthus amarus' Supplementation Alleviates Fasting Blood Glucose and Oxidative Stress in Overweight and Obese Individuals |
| title_sort | square stepping hiit combined with phyllanthus amarus supplementation alleviates fasting blood glucose and oxidative stress in overweight and obese individuals |
| topic | aerobic exercise physical activity antioxidant supplement oxidative stress |
| url | https://account.paahjournal.com/index.php/up-j-pah/article/view/400 |
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