The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses
Exposure to environmental contaminants can result in profound effects on the host immune system. One class of environmental toxicants, known as dioxins, are persistent environmental contaminants termed “forever chemicals”. The archetype toxicant from this group of chemicals is 2, 3, 7, 8-tetrachloro...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497405/full |
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| author | Victoria R. Stephens Kensley B. Horner Walter M. Avila Sabrina K. Spicer Riya Chinni Emily B. Bernabe Antentor O. Hinton Steven M. Damo Steven M. Damo Steven M. Damo Alison J. Eastman Monique M. McCallister Kevin G. Osteen Kevin G. Osteen Kevin G. Osteen Kevin G. Osteen Jennifer A. Gaddy Jennifer A. Gaddy Jennifer A. Gaddy Jennifer A. Gaddy |
| author_facet | Victoria R. Stephens Kensley B. Horner Walter M. Avila Sabrina K. Spicer Riya Chinni Emily B. Bernabe Antentor O. Hinton Steven M. Damo Steven M. Damo Steven M. Damo Alison J. Eastman Monique M. McCallister Kevin G. Osteen Kevin G. Osteen Kevin G. Osteen Kevin G. Osteen Jennifer A. Gaddy Jennifer A. Gaddy Jennifer A. Gaddy Jennifer A. Gaddy |
| author_sort | Victoria R. Stephens |
| collection | DOAJ |
| description | Exposure to environmental contaminants can result in profound effects on the host immune system. One class of environmental toxicants, known as dioxins, are persistent environmental contaminants termed “forever chemicals”. The archetype toxicant from this group of chemicals is 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), an immunotoxicant that activates the aryl-hydrocarbon receptor pathway leading to a variety of changes in immune cell responses. Immune cell functions are crucial to the development and maintenance of healthy reproduction. Immune cells facilitate tolerance between at the maternal-fetal interface between the parent and the semi-allogenic fetus and help defend the gravid reproductive tract from infectious assault. Epidemiological studies reveal that exposure to environmental contaminants (such as TCDD) are linked to adverse reproductive health outcomes including endometriosis, placental inflammation, and preterm birth. However, little is known about the molecular mechanisms that underpin how environmental toxicant exposures impact immune functions at the maternal-fetal interface or within the reproductive tract in general. This review presents the most recent published work that studies interactions between dioxin or TCDD exposure, the host immune system, and reproduction. |
| format | Article |
| id | doaj-art-bc54c466f4ce4cff912cacd846508bf6 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-bc54c466f4ce4cff912cacd846508bf62025-08-20T01:59:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14974051497405The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responsesVictoria R. Stephens0Kensley B. Horner1Walter M. Avila2Sabrina K. Spicer3Riya Chinni4Emily B. Bernabe5Antentor O. Hinton6Steven M. Damo7Steven M. Damo8Steven M. Damo9Alison J. Eastman10Monique M. McCallister11Kevin G. Osteen12Kevin G. Osteen13Kevin G. Osteen14Kevin G. Osteen15Jennifer A. Gaddy16Jennifer A. Gaddy17Jennifer A. Gaddy18Jennifer A. Gaddy19Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Life and Physical Sciences, Fisk University, Nashville, TN, United StatesDepartment of Life and Physical Sciences, Fisk University, Nashville, TN, United StatesDepartment of Chemistry, Vanderbilt University, Nashville, TN, United StatesDepartment of Medicine, Health, and Society, Vanderbilt University, Nashville, TN, United StatesTennessee Valley Health Systems, Department of Veterans Affairs, Nashville, TN, United StatesDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United StatesDepartment of Life and Physical Sciences, Fisk University, Nashville, TN, United StatesDepartment of Biochemistry, Vanderbilt University, Nashville, TN, United StatesCenter for Structural Biology, Vanderbilt University, Nashville, TN, United StatesDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, United States0Department of Biological Sciences, Tennessee State University, Nashville, TN, United StatesDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United StatesTennessee Valley Health Systems, Department of Veterans Affairs, Nashville, TN, United StatesDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, United States1Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, TN, United StatesDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United StatesDepartment of Medicine, Health, and Society, Vanderbilt University, Nashville, TN, United StatesTennessee Valley Health Systems, Department of Veterans Affairs, Nashville, TN, United States2Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United StatesExposure to environmental contaminants can result in profound effects on the host immune system. One class of environmental toxicants, known as dioxins, are persistent environmental contaminants termed “forever chemicals”. The archetype toxicant from this group of chemicals is 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), an immunotoxicant that activates the aryl-hydrocarbon receptor pathway leading to a variety of changes in immune cell responses. Immune cell functions are crucial to the development and maintenance of healthy reproduction. Immune cells facilitate tolerance between at the maternal-fetal interface between the parent and the semi-allogenic fetus and help defend the gravid reproductive tract from infectious assault. Epidemiological studies reveal that exposure to environmental contaminants (such as TCDD) are linked to adverse reproductive health outcomes including endometriosis, placental inflammation, and preterm birth. However, little is known about the molecular mechanisms that underpin how environmental toxicant exposures impact immune functions at the maternal-fetal interface or within the reproductive tract in general. This review presents the most recent published work that studies interactions between dioxin or TCDD exposure, the host immune system, and reproduction.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497405/fullenvironmental toxicantTCDDdioxininnate immunityreproduction |
| spellingShingle | Victoria R. Stephens Kensley B. Horner Walter M. Avila Sabrina K. Spicer Riya Chinni Emily B. Bernabe Antentor O. Hinton Steven M. Damo Steven M. Damo Steven M. Damo Alison J. Eastman Monique M. McCallister Kevin G. Osteen Kevin G. Osteen Kevin G. Osteen Kevin G. Osteen Jennifer A. Gaddy Jennifer A. Gaddy Jennifer A. Gaddy Jennifer A. Gaddy The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses Frontiers in Immunology environmental toxicant TCDD dioxin innate immunity reproduction |
| title | The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses |
| title_full | The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses |
| title_fullStr | The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses |
| title_full_unstemmed | The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses |
| title_short | The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses |
| title_sort | impact of persistent organic pollutants on fertility exposure to the environmental toxicant 2 3 7 8 tetrachlorodibenzo p dioxin alters reproductive tract immune responses |
| topic | environmental toxicant TCDD dioxin innate immunity reproduction |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497405/full |
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