Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics
The gut microbiota is essential for overall health, and in recent years, there has been increasing interest in its complex relationship with the “gut-liver-kidney axis.” In this research, we aim to examine how the gut microbiota affects metabolic and immune responses via influencing the functions of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554458/full |
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| author | Dai-Liang Fei Ying Liu Jia Liu Ze Yu Jin-Liang Dong |
| author_facet | Dai-Liang Fei Ying Liu Jia Liu Ze Yu Jin-Liang Dong |
| author_sort | Dai-Liang Fei |
| collection | DOAJ |
| description | The gut microbiota is essential for overall health, and in recent years, there has been increasing interest in its complex relationship with the “gut-liver-kidney axis.” In this research, we aim to examine how the gut microbiota affects metabolic and immune responses via influencing the functions of the liver and kidneys. It will also analyze potential pathological mechanisms involved in this interaction and discuss therapeutic strategies that focus on modulating the gut microbiota. Through thoroughly reviewing existing literature, this article intends to offer fresh perspectives and insights that could inform future research and clinical applications in this rapidly developing area of study. |
| format | Article |
| id | doaj-art-bc547aee27c443ca9c6db985b6c371fe |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-bc547aee27c443ca9c6db985b6c371fe2025-08-20T02:36:02ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-06-011610.3389/fmicb.2025.15544581554458Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeuticsDai-Liang Fei0Ying Liu1Jia Liu2Ze Yu3Jin-Liang Dong4Department of General Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, ChinaDepartment of Pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, ChinaSchool of Agriculture, Sun Yat-sen University, Shenzhen, Guangdong, ChinaThe Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, ChinaDepartment of General Surgery, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, ChinaThe gut microbiota is essential for overall health, and in recent years, there has been increasing interest in its complex relationship with the “gut-liver-kidney axis.” In this research, we aim to examine how the gut microbiota affects metabolic and immune responses via influencing the functions of the liver and kidneys. It will also analyze potential pathological mechanisms involved in this interaction and discuss therapeutic strategies that focus on modulating the gut microbiota. Through thoroughly reviewing existing literature, this article intends to offer fresh perspectives and insights that could inform future research and clinical applications in this rapidly developing area of study.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554458/fullgut microbiotagut-liver-kidney axismechanismstherapeuticsmetabolism |
| spellingShingle | Dai-Liang Fei Ying Liu Jia Liu Ze Yu Jin-Liang Dong Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics Frontiers in Microbiology gut microbiota gut-liver-kidney axis mechanisms therapeutics metabolism |
| title | Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics |
| title_full | Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics |
| title_fullStr | Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics |
| title_full_unstemmed | Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics |
| title_short | Gut microbiota and the “gut-liver-kidney axis” theory: from mechanisms to therapeutics |
| title_sort | gut microbiota and the gut liver kidney axis theory from mechanisms to therapeutics |
| topic | gut microbiota gut-liver-kidney axis mechanisms therapeutics metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554458/full |
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