PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS
The goal of the study is to assess the changes in spontaneous and antigen-induced production of macrophages and interleukin-8 in destructive tuberculosis patients during the intensive phase of treatment. The cultures of whole blood of 38 destructive tuberculosis patients were used as a source of mac...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2015-08-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/785 |
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| author | M. M. Averbakh (Jr.) L. V. Panova E. S. Ovsyankina |
| author_facet | M. M. Averbakh (Jr.) L. V. Panova E. S. Ovsyankina |
| author_sort | M. M. Averbakh (Jr.) |
| collection | DOAJ |
| description | The goal of the study is to assess the changes in spontaneous and antigen-induced production of macrophages and interleukin-8 in destructive tuberculosis patients during the intensive phase of treatment. The cultures of whole blood of 38 destructive tuberculosis patients were used as a source of macrophages and interleukin-8 production, and the patients were divided depending on procalcitonin semiquantitative test (BRAHMS PCT-Q) results into the group of PCT+ (15 patients) and the group of PCT- (23 patients). Production of macrophages and interleukin-8 were assessed in the cultured blood for 20-22 hours. Antigen-induced synthesis of macrophages was assessed after adding 20 mkg/ml of PPD or 1 mkg/ml of ESAT 6/CFP 10. Production of cytokines was tested by enzyme immunoassay. It has been found that the rates of spontaneous production of macrophages or interleukin-8 in the cultured blood reflect the changes in the production of these factors and can be used without consideration of antigen-induced synthesis; spontaneous production of macrophages in patients with positive test for PCT confidently decreases and production of IL-8 confidently goes up by the 2nd month of anti-tuberculosis chemotherapy; changes in spontaneous production of macrophages di}er in patients with the various course of destructive tuberculosis (favorable, torpid, progressing). In the favorable course of the disease production of macrophages increases, in torpid or progressing ones – goes down or stays unchanged. |
| format | Article |
| id | doaj-art-bc53f4b27da4468a94c966f7e59ae890 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2015-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-bc53f4b27da4468a94c966f7e59ae8902025-08-20T02:05:56ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062015-08-0108434710.21292/2075-1230-2015-0-8-43-47785PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSISM. M. Averbakh (Jr.)0L. V. Panova1E. S. Ovsyankina2Central Tuberculosis Research InstituteCentral Tuberculosis Research InstituteCentral Tuberculosis Research InstituteThe goal of the study is to assess the changes in spontaneous and antigen-induced production of macrophages and interleukin-8 in destructive tuberculosis patients during the intensive phase of treatment. The cultures of whole blood of 38 destructive tuberculosis patients were used as a source of macrophages and interleukin-8 production, and the patients were divided depending on procalcitonin semiquantitative test (BRAHMS PCT-Q) results into the group of PCT+ (15 patients) and the group of PCT- (23 patients). Production of macrophages and interleukin-8 were assessed in the cultured blood for 20-22 hours. Antigen-induced synthesis of macrophages was assessed after adding 20 mkg/ml of PPD or 1 mkg/ml of ESAT 6/CFP 10. Production of cytokines was tested by enzyme immunoassay. It has been found that the rates of spontaneous production of macrophages or interleukin-8 in the cultured blood reflect the changes in the production of these factors and can be used without consideration of antigen-induced synthesis; spontaneous production of macrophages in patients with positive test for PCT confidently decreases and production of IL-8 confidently goes up by the 2nd month of anti-tuberculosis chemotherapy; changes in spontaneous production of macrophages di}er in patients with the various course of destructive tuberculosis (favorable, torpid, progressing). In the favorable course of the disease production of macrophages increases, in torpid or progressing ones – goes down or stays unchanged.https://www.tibl-journal.com/jour/article/view/785macrophages migration inhibition factorsinterleukin-8childrenadolescentsdestructive pulmonary tuberculosis |
| spellingShingle | M. M. Averbakh (Jr.) L. V. Panova E. S. Ovsyankina PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS Туберкулез и болезни лёгких macrophages migration inhibition factors interleukin-8 children adolescents destructive pulmonary tuberculosis |
| title | PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS |
| title_full | PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS |
| title_fullStr | PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS |
| title_full_unstemmed | PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS |
| title_short | PRODUCTION OF MACROPHAGE AND INTERLEUKIN-8 MIGRATION INHIBITION FACTOR IN CHILDREN AND ADOLESCENTS SUFFERING FROM DESTRUCTIVE PULMONARY TUBERCULOSIS |
| title_sort | production of macrophage and interleukin 8 migration inhibition factor in children and adolescents suffering from destructive pulmonary tuberculosis |
| topic | macrophages migration inhibition factors interleukin-8 children adolescents destructive pulmonary tuberculosis |
| url | https://www.tibl-journal.com/jour/article/view/785 |
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