Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review
High-grade myofibroblastic sarcoma (HGMS) is exceedingly rare and highly aggressive, with a poor prognosis. Currently, there is no consensus on its definition. Wide resection is the standard of care for most patients, but clinical data on treatment outcomes remain limited. Here, we present the first...
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| Format: | Article |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525401/full |
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| author | Xiaofeng He Min Lv Jin Yuan Jun He Xuemei Du Yang Yang Hong Zhang Feng Wen |
| author_facet | Xiaofeng He Min Lv Jin Yuan Jun He Xuemei Du Yang Yang Hong Zhang Feng Wen |
| author_sort | Xiaofeng He |
| collection | DOAJ |
| description | High-grade myofibroblastic sarcoma (HGMS) is exceedingly rare and highly aggressive, with a poor prognosis. Currently, there is no consensus on its definition. Wide resection is the standard of care for most patients, but clinical data on treatment outcomes remain limited. Here, we present the first reported case of HGMS originating intracranially. Surgical excision of the tumor was performed, followed by adjuvant radiotherapy with a total dose of 60 Gy in 30 fractions. As of November 2024, the patient had achieved 24 months of recurrence-free survival. This case may provide new evidence that could be useful for the treatment of rare primary intracranial HGMS. |
| format | Article |
| id | doaj-art-bc52dd60d6c345ce9ec883b713998c8d |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bc52dd60d6c345ce9ec883b713998c8d2025-08-20T02:54:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15254011525401Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature reviewXiaofeng He0Min Lv1Jin Yuan2Jun He3Xuemei Du4Yang Yang5Hong Zhang6Feng Wen7Department of Medical Oncology, The First People’s Hospital of Longquanyi District, Chengdu, Chengdu, Sichuan, ChinaDepartment of Medical Oncology, The First People’s Hospital of Longquanyi District, Chengdu, Chengdu, Sichuan, ChinaDepartment of Medical Oncology, The First People’s Hospital of Longquanyi District, Chengdu, Chengdu, Sichuan, ChinaDepartment of Radiology, The First People’s Hospital of Longquanyi District, Chengdu, Chengdu, Sichuan, ChinaDepartment of Pathology, The First People’s Hospital of Longquanyi District, Chengdu, Chengdu, Sichuan, ChinaDepartment of Medical Oncology, The First People’s Hospital of Longquanyi District, Chengdu, Chengdu, Sichuan, ChinaDepartment of Radiation Oncology and Department of Head & Neck Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaAbdominal Oncology Ward, Division of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaHigh-grade myofibroblastic sarcoma (HGMS) is exceedingly rare and highly aggressive, with a poor prognosis. Currently, there is no consensus on its definition. Wide resection is the standard of care for most patients, but clinical data on treatment outcomes remain limited. Here, we present the first reported case of HGMS originating intracranially. Surgical excision of the tumor was performed, followed by adjuvant radiotherapy with a total dose of 60 Gy in 30 fractions. As of November 2024, the patient had achieved 24 months of recurrence-free survival. This case may provide new evidence that could be useful for the treatment of rare primary intracranial HGMS.https://www.frontiersin.org/articles/10.3389/fonc.2025.1525401/fullprimary intracranialhigh-grade myofibroblastic sarcomaresectionradiotherapycase report |
| spellingShingle | Xiaofeng He Min Lv Jin Yuan Jun He Xuemei Du Yang Yang Hong Zhang Feng Wen Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review Frontiers in Oncology primary intracranial high-grade myofibroblastic sarcoma resection radiotherapy case report |
| title | Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review |
| title_full | Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review |
| title_fullStr | Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review |
| title_full_unstemmed | Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review |
| title_short | Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review |
| title_sort | case report primary intracranial high grade myofibroblastic sarcoma and literature review |
| topic | primary intracranial high-grade myofibroblastic sarcoma resection radiotherapy case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525401/full |
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