Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC

Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignant tumor characterized by a complex tumor microenvironment (TME) with significant heterogeneity, posing immense challenges for devising effective therapeutic strategies. This study aims to elucidate the dynamic changes in the...

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Bibliographic Details
Main Authors: Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Pancreatic ductal adenocarcinoma
Single-cell RNA sequencing
Tumor microenvironment
Prognosis signature
Drug prediction
Online Access:https://doi.org/10.1038/s41598-025-86950-8
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