SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications
SARS-CoV-2 has been the causative pathogen of the pandemic of COVID-19, resulting in catastrophic health issues globally. It is important to develop human-like animal models for investigating the mechanisms that SARS-CoV-2 uses to infect humans and cause COVID-19. Several studies demonstrated that t...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2021.1976598 |
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| author | Lunzhi Yuan Qiyi Tang Huachen Zhu Yi Guan Tong Cheng Ningshao Xia |
| author_facet | Lunzhi Yuan Qiyi Tang Huachen Zhu Yi Guan Tong Cheng Ningshao Xia |
| author_sort | Lunzhi Yuan |
| collection | DOAJ |
| description | SARS-CoV-2 has been the causative pathogen of the pandemic of COVID-19, resulting in catastrophic health issues globally. It is important to develop human-like animal models for investigating the mechanisms that SARS-CoV-2 uses to infect humans and cause COVID-19. Several studies demonstrated that the non-human primate (NHP) is permissive for SARS-CoV-2 infection to cause typical clinical symptoms including fever, cough, breathing difficulty, and other diagnostic abnormalities such as immunopathogenesis and hyperplastic lesions in the lung. These NHP models have been used for investigating the potential infection route and host immune response to SARS-CoV-2, as well as testing vaccines and drugs. This review aims to summarize the benefits and caveats of NHP models currently available for SARS-CoV-2, and to discuss key topics including model optimization, extended application, and clinical translation. |
| format | Article |
| id | doaj-art-bc48129502fb4389a514bf643f589ec5 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-bc48129502fb4389a514bf643f589ec52025-08-20T03:52:56ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512021-01-011011881188910.1080/22221751.2021.1976598SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implicationsLunzhi Yuan0Qiyi Tang1Huachen Zhu2Yi Guan3Tong Cheng4Ningshao Xia5State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaDepartment of Microbiology, Howard University College of Medicine, Washington, DC, USAState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People’s Republic of ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, People’s Republic of ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, People’s Republic of ChinaSARS-CoV-2 has been the causative pathogen of the pandemic of COVID-19, resulting in catastrophic health issues globally. It is important to develop human-like animal models for investigating the mechanisms that SARS-CoV-2 uses to infect humans and cause COVID-19. Several studies demonstrated that the non-human primate (NHP) is permissive for SARS-CoV-2 infection to cause typical clinical symptoms including fever, cough, breathing difficulty, and other diagnostic abnormalities such as immunopathogenesis and hyperplastic lesions in the lung. These NHP models have been used for investigating the potential infection route and host immune response to SARS-CoV-2, as well as testing vaccines and drugs. This review aims to summarize the benefits and caveats of NHP models currently available for SARS-CoV-2, and to discuss key topics including model optimization, extended application, and clinical translation.https://www.tandfonline.com/doi/10.1080/22221751.2021.1976598SARS-CoV-2non-human primatessevere acute respiratory syndromeimmunopathogenesisvaccine and drug discovery |
| spellingShingle | Lunzhi Yuan Qiyi Tang Huachen Zhu Yi Guan Tong Cheng Ningshao Xia SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications Emerging Microbes and Infections SARS-CoV-2 non-human primates severe acute respiratory syndrome immunopathogenesis vaccine and drug discovery |
| title | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications |
| title_full | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications |
| title_fullStr | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications |
| title_full_unstemmed | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications |
| title_short | SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications |
| title_sort | sars cov 2 infection and disease outcomes in non human primate models advances and implications |
| topic | SARS-CoV-2 non-human primates severe acute respiratory syndrome immunopathogenesis vaccine and drug discovery |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2021.1976598 |
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