Thiol-thiol cross-clicking using bromo-ynone reagents

Abstract Thiols are used in many click reactions, and are also excellent platforms for biomolecular click or bioconjugation reactions. The direct cross-coupling of two thiols is an attractive biomimetic concept for click chemistry, but leads to statistical mixtures of homo- and heterodimers. Here, w...

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Bibliographic Details
Main Authors: Marvin Nicque, Jan H. Meffert, Diederick Maes, Kevin Bevernaege, Mehwish Iftikhar, Olivier Zwaenepoel, Jan Gettemans, Annemieke Madder, Johan M. Winne
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61682-5
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