Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures
Objective. To determine minimal clinically significant changes of quality of life (QL) measures in pts with rheumatoid arthritis (RA) and to develop criteria for therapy efficacy assessment by QL measures. Material and methods. 258 pts with RA fulfilled ACR criteria and receiving standard antirheuma...
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| Language: | Russian |
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IMA PRESS LLC
2007-10-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/312 |
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| author | V. N. Antirdjanova |
| author_facet | V. N. Antirdjanova |
| author_sort | V. N. Antirdjanova |
| collection | DOAJ |
| description | Objective. To determine minimal clinically significant changes of quality of life (QL) measures in pts with rheumatoid arthritis (RA) and to develop criteria for therapy efficacy assessment by QL measures. Material and methods. 258 pts with RA fulfilled ACR criteria and receiving standard antirheumatic therapy were assessed at baseline and after 6 months of follow up. The mean age was 51,4± 11,6 years, duration of the disease varied from 1 to 18 years (mean 9,0±8,7 years). 58,8% of pts had rheumatoid factor. 39,9% of pts had moderate and 54,3% - high activity of the disease according to DAS 28. 50,4% of pts had III or IV radiological stage, 42,7% of pts had III or IV functional class (FC). All pts filled validated HAQ, EQ-5D and SF-36 questionnaires. Therapy efficacy was assessed by ACR criteria. Minimal clinically significant changes (MCSC) were calculated according to effect value (EV). EV accordance to difference of QL measures before and after treatment was determined. Results. Minimal difference of values which was interpreted by pts as significant was 0,22 for HAQ, and 0,10 for EQ-5D. Therapy efficacy assessment can be done with following HAQ diapasons. Treatment is not effective if HAQ decrease is less than 0,22. Weak improvement corresponds to HAQ decrease from 0,22 to 0,36. 0,36<AHAQ<0,8 shows moderate improvement and AHAQ£0,8 can be interpreted as good effect. Therapy efficacy assessment with EQ-5D can be performed as follows. Therapy is not effective when AEQ- 5D<0,1. 0,1<AEQ-5D<0,24 corresponds to weak, 0,24<AEQ-5D<0,31 — to moderate and AEQ-5D>0,31 to good clinical response. Conclusion. General QL questionnaires EQ-5D and SF-36 are less sensitive than HAQ in assessment of therapy efficacy. |
| format | Article |
| id | doaj-art-bc3d3d5fab584977afe851f98f1aef73 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2007-10-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-bc3d3d5fab584977afe851f98f1aef732025-08-20T03:21:50ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922007-10-01455939910.14412/1995-4484-2007-28252Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measuresV. N. AntirdjanovaObjective. To determine minimal clinically significant changes of quality of life (QL) measures in pts with rheumatoid arthritis (RA) and to develop criteria for therapy efficacy assessment by QL measures. Material and methods. 258 pts with RA fulfilled ACR criteria and receiving standard antirheumatic therapy were assessed at baseline and after 6 months of follow up. The mean age was 51,4± 11,6 years, duration of the disease varied from 1 to 18 years (mean 9,0±8,7 years). 58,8% of pts had rheumatoid factor. 39,9% of pts had moderate and 54,3% - high activity of the disease according to DAS 28. 50,4% of pts had III or IV radiological stage, 42,7% of pts had III or IV functional class (FC). All pts filled validated HAQ, EQ-5D and SF-36 questionnaires. Therapy efficacy was assessed by ACR criteria. Minimal clinically significant changes (MCSC) were calculated according to effect value (EV). EV accordance to difference of QL measures before and after treatment was determined. Results. Minimal difference of values which was interpreted by pts as significant was 0,22 for HAQ, and 0,10 for EQ-5D. Therapy efficacy assessment can be done with following HAQ diapasons. Treatment is not effective if HAQ decrease is less than 0,22. Weak improvement corresponds to HAQ decrease from 0,22 to 0,36. 0,36<AHAQ<0,8 shows moderate improvement and AHAQ£0,8 can be interpreted as good effect. Therapy efficacy assessment with EQ-5D can be performed as follows. Therapy is not effective when AEQ- 5D<0,1. 0,1<AEQ-5D<0,24 corresponds to weak, 0,24<AEQ-5D<0,31 — to moderate and AEQ-5D>0,31 to good clinical response. Conclusion. General QL questionnaires EQ-5D and SF-36 are less sensitive than HAQ in assessment of therapy efficacy.https://rsp.mediar-press.net/rsp/article/view/312rheumatoid arthritisql questionnairesminimal clinically significant changestherapy efficacy |
| spellingShingle | V. N. Antirdjanova Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures Научно-практическая ревматология rheumatoid arthritis ql questionnaires minimal clinically significant changes therapy efficacy |
| title | Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures |
| title_full | Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures |
| title_fullStr | Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures |
| title_full_unstemmed | Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures |
| title_short | Therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures |
| title_sort | therapy efficacy assessment in patients with rheumatoid arthritis by quality of life measures |
| topic | rheumatoid arthritis ql questionnaires minimal clinically significant changes therapy efficacy |
| url | https://rsp.mediar-press.net/rsp/article/view/312 |
| work_keys_str_mv | AT vnantirdjanova therapyefficacyassessmentinpatientswithrheumatoidarthritisbyqualityoflifemeasures |