Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients
Objectives. This study aimed to investigate the association between inflammation-related microRNAs (miR-21, 146a, 155) and the plaque stability in coronary artery disease patients. Methods. The expression of miR-21, 146a, and 155 was measured by real-time PCR in 310 consecutive patients. The level o...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2019/9723129 |
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| _version_ | 1850178633966026752 |
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| author | Guo-fu Zhu Tianshu Chu Zhimin Ruan Mingguo Zhang Mingli Zhou Qian Zhang Ran Zhang Liyong Wu |
| author_facet | Guo-fu Zhu Tianshu Chu Zhimin Ruan Mingguo Zhang Mingli Zhou Qian Zhang Ran Zhang Liyong Wu |
| author_sort | Guo-fu Zhu |
| collection | DOAJ |
| description | Objectives. This study aimed to investigate the association between inflammation-related microRNAs (miR-21, 146a, 155) and the plaque stability in coronary artery disease patients. Methods. The expression of miR-21, 146a, and 155 was measured by real-time PCR in 310 consecutive patients. The level of hs-CRP, IL-6, and IL-8 was measured by ELISA. The plaque stability of coronary stenotic lesions was evaluated with intravascular ultrasound (IVUS). Results. (1) The levels of hs-CRP, IL-6, and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS group (P<0.01). (2) The expression of miR-21 and miR-146a in peripheral blood mononuclear cells (PBMCs) and plasma was significantly higher in CAD patients compared with non-CAD patients, whereas the miR-155 expression in PBMCs and plasma was significantly lower in patients with CAD. (3) The miR-21 expression in PBMCs was higher in UAP and AMI groups compared with CPS group. The miR-146a expression in PBMCs was higher in SAP, UAP, and AMI groups than in CPS group. Although the level of miR-155 in PBMCs was lower in SAP, UAP, and AMI groups than in CPS group. The expression patterns of miR-21, miR-146a, and miR-155 in plasma were consistent with those of PBMCs. (4) The expressions of miR-21 and miR-146a in PBMCs and plasma were significantly higher in the vulnerable plaque group than those in stable plaque group. While miR-155 in PBMCs and plasma was significantly lower in vulnerable plaque group compared with stable plaque group. (5) The levels of miR-21 and miR-146a in PBMCs and plasma were significantly higher in soft plaque group than in fibrous plaque group and calcified plaque group. However, miR-155 in PBMCs and plasma was significantly lower in soft plaque group. Conclusions. The expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability. |
| format | Article |
| id | doaj-art-bc3baa5140c841a58ddb301179b6c4a9 |
| institution | OA Journals |
| issn | 0896-4327 1540-8183 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-bc3baa5140c841a58ddb301179b6c4a92025-08-20T02:18:42ZengWileyJournal of Interventional Cardiology0896-43271540-81832019-01-01201910.1155/2019/97231299723129Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease PatientsGuo-fu Zhu0Tianshu Chu1Zhimin Ruan2Mingguo Zhang3Mingli Zhou4Qian Zhang5Ran Zhang6Liyong Wu7Department of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, ChinaObjectives. This study aimed to investigate the association between inflammation-related microRNAs (miR-21, 146a, 155) and the plaque stability in coronary artery disease patients. Methods. The expression of miR-21, 146a, and 155 was measured by real-time PCR in 310 consecutive patients. The level of hs-CRP, IL-6, and IL-8 was measured by ELISA. The plaque stability of coronary stenotic lesions was evaluated with intravascular ultrasound (IVUS). Results. (1) The levels of hs-CRP, IL-6, and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS group (P<0.01). (2) The expression of miR-21 and miR-146a in peripheral blood mononuclear cells (PBMCs) and plasma was significantly higher in CAD patients compared with non-CAD patients, whereas the miR-155 expression in PBMCs and plasma was significantly lower in patients with CAD. (3) The miR-21 expression in PBMCs was higher in UAP and AMI groups compared with CPS group. The miR-146a expression in PBMCs was higher in SAP, UAP, and AMI groups than in CPS group. Although the level of miR-155 in PBMCs was lower in SAP, UAP, and AMI groups than in CPS group. The expression patterns of miR-21, miR-146a, and miR-155 in plasma were consistent with those of PBMCs. (4) The expressions of miR-21 and miR-146a in PBMCs and plasma were significantly higher in the vulnerable plaque group than those in stable plaque group. While miR-155 in PBMCs and plasma was significantly lower in vulnerable plaque group compared with stable plaque group. (5) The levels of miR-21 and miR-146a in PBMCs and plasma were significantly higher in soft plaque group than in fibrous plaque group and calcified plaque group. However, miR-155 in PBMCs and plasma was significantly lower in soft plaque group. Conclusions. The expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability.http://dx.doi.org/10.1155/2019/9723129 |
| spellingShingle | Guo-fu Zhu Tianshu Chu Zhimin Ruan Mingguo Zhang Mingli Zhou Qian Zhang Ran Zhang Liyong Wu Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients Journal of Interventional Cardiology |
| title | Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients |
| title_full | Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients |
| title_fullStr | Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients |
| title_full_unstemmed | Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients |
| title_short | Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients |
| title_sort | inflammation related micrornas are associated with plaque stability calculated by ivus in coronary heart disease patients |
| url | http://dx.doi.org/10.1155/2019/9723129 |
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