Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex
Homeostatic plasticity regulates synaptic activity by preventing uncontrolled increases (long-term potentiation) or decreases (long-term depression) in synaptic efficacy. Homeostatic plasticity can be induced and assessed in the human primary motor cortex (M1) using noninvasive brain stimulation. Ho...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/6207508 |
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| author | Tribikram Thapa Siobhan M. Schabrun |
| author_facet | Tribikram Thapa Siobhan M. Schabrun |
| author_sort | Tribikram Thapa |
| collection | DOAJ |
| description | Homeostatic plasticity regulates synaptic activity by preventing uncontrolled increases (long-term potentiation) or decreases (long-term depression) in synaptic efficacy. Homeostatic plasticity can be induced and assessed in the human primary motor cortex (M1) using noninvasive brain stimulation. However, the reliability of this methodology has not been investigated. Here, we examined the test-retest reliability of homeostatic plasticity induced and assessed in M1 using noninvasive brain stimulation in ten, right-handed, healthy volunteers on days 0, 2, 7, and 14. Homeostatic plasticity was induced in the left M1 using two blocks of anodal transcranial direct current stimulation (tDCS) applied for 7 min and 5 min, separated by a 3 min interval. To assess homeostatic plasticity, 15 motor-evoked potentials to single-pulse transcranial magnetic stimulation were recorded at baseline, between the two blocks of anodal tDCS, and at 0 min, 10 min, and 20 min follow-up. Test-retest reliability was evaluated using intraclass correlation coefficients (ICCs). Moderate-to-good test-retest reliability was observed for the M1 homeostatic plasticity response at all follow-up time points (0 min, 10 min, and 20 min, ICC range: 0.43–0.67) at intervals up to 2 weeks. The greatest reliability was observed when the homeostatic response was assessed at 10 min follow-up (ICC>0.61). These data suggest that M1 homeostatic plasticity can be reliably induced and assessed in healthy individuals using two blocks of anodal tDCS at intervals of 48 hours, 7 days, and 2 weeks. |
| format | Article |
| id | doaj-art-bc3b168ff6534507a24b52a7d09ac14c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-bc3b168ff6534507a24b52a7d09ac14c2025-02-03T06:04:59ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/62075086207508Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor CortexTribikram Thapa0Siobhan M. Schabrun1Brain Rehabilitation and Neuroplasticity Unit, School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, AustraliaBrain Rehabilitation and Neuroplasticity Unit, School of Science and Health, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, AustraliaHomeostatic plasticity regulates synaptic activity by preventing uncontrolled increases (long-term potentiation) or decreases (long-term depression) in synaptic efficacy. Homeostatic plasticity can be induced and assessed in the human primary motor cortex (M1) using noninvasive brain stimulation. However, the reliability of this methodology has not been investigated. Here, we examined the test-retest reliability of homeostatic plasticity induced and assessed in M1 using noninvasive brain stimulation in ten, right-handed, healthy volunteers on days 0, 2, 7, and 14. Homeostatic plasticity was induced in the left M1 using two blocks of anodal transcranial direct current stimulation (tDCS) applied for 7 min and 5 min, separated by a 3 min interval. To assess homeostatic plasticity, 15 motor-evoked potentials to single-pulse transcranial magnetic stimulation were recorded at baseline, between the two blocks of anodal tDCS, and at 0 min, 10 min, and 20 min follow-up. Test-retest reliability was evaluated using intraclass correlation coefficients (ICCs). Moderate-to-good test-retest reliability was observed for the M1 homeostatic plasticity response at all follow-up time points (0 min, 10 min, and 20 min, ICC range: 0.43–0.67) at intervals up to 2 weeks. The greatest reliability was observed when the homeostatic response was assessed at 10 min follow-up (ICC>0.61). These data suggest that M1 homeostatic plasticity can be reliably induced and assessed in healthy individuals using two blocks of anodal tDCS at intervals of 48 hours, 7 days, and 2 weeks.http://dx.doi.org/10.1155/2018/6207508 |
| spellingShingle | Tribikram Thapa Siobhan M. Schabrun Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex Neural Plasticity |
| title | Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex |
| title_full | Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex |
| title_fullStr | Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex |
| title_full_unstemmed | Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex |
| title_short | Test-Retest Reliability of Homeostatic Plasticity in the Human Primary Motor Cortex |
| title_sort | test retest reliability of homeostatic plasticity in the human primary motor cortex |
| url | http://dx.doi.org/10.1155/2018/6207508 |
| work_keys_str_mv | AT tribikramthapa testretestreliabilityofhomeostaticplasticityinthehumanprimarymotorcortex AT siobhanmschabrun testretestreliabilityofhomeostaticplasticityinthehumanprimarymotorcortex |