Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature
Acute promyelocytic leukemia (APL) during pregnancy is an exceptionally rare occurrence with high maternal and fetal mortality rates, requiring a highly tailored approach to therapy. We report a case of a patient diagnosed with APL during the third trimester of pregnancy who initially presented with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Hematology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/frhem.2025.1553336/full |
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| author | Sirichai Puttirangsan B. Prasertkanchana Natnipa Parapob Sirichai Srichairatanakool Thanawat Rattanathammethee |
| author_facet | Sirichai Puttirangsan B. Prasertkanchana Natnipa Parapob Sirichai Srichairatanakool Thanawat Rattanathammethee |
| author_sort | Sirichai Puttirangsan |
| collection | DOAJ |
| description | Acute promyelocytic leukemia (APL) during pregnancy is an exceptionally rare occurrence with high maternal and fetal mortality rates, requiring a highly tailored approach to therapy. We report a case of a patient diagnosed with APL during the third trimester of pregnancy who initially presented with spontaneous ecchymoses. Treatment was initiated with all-trans retinoic acid (ATRA) and a modified dose of idarubicin, leading to a rapid correction of the coagulopathy and a complete remission of the APL. The patient subsequently underwent induced labor, resulting in an uncomplicated vaginal delivery without significant hemorrhage and no evidence of embryopathy in the neonate. To date, no published reports of successful deliveries in patients with APL have been documented in Thailand. This case highlights how a multidisciplinary approach involving obstetricians, hematologists, and neonatologists ensured both maternal survival and optimal neonatal outcomes. |
| format | Article |
| id | doaj-art-bc3a12e03ecc401ca229a08be7d40a05 |
| institution | OA Journals |
| issn | 2813-3935 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Hematology |
| spelling | doaj-art-bc3a12e03ecc401ca229a08be7d40a052025-08-20T02:35:56ZengFrontiers Media S.A.Frontiers in Hematology2813-39352025-06-01410.3389/frhem.2025.15533361553336Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literatureSirichai Puttirangsan0B. Prasertkanchana1Natnipa Parapob2Sirichai Srichairatanakool3Thanawat Rattanathammethee4Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandAcute promyelocytic leukemia (APL) during pregnancy is an exceptionally rare occurrence with high maternal and fetal mortality rates, requiring a highly tailored approach to therapy. We report a case of a patient diagnosed with APL during the third trimester of pregnancy who initially presented with spontaneous ecchymoses. Treatment was initiated with all-trans retinoic acid (ATRA) and a modified dose of idarubicin, leading to a rapid correction of the coagulopathy and a complete remission of the APL. The patient subsequently underwent induced labor, resulting in an uncomplicated vaginal delivery without significant hemorrhage and no evidence of embryopathy in the neonate. To date, no published reports of successful deliveries in patients with APL have been documented in Thailand. This case highlights how a multidisciplinary approach involving obstetricians, hematologists, and neonatologists ensured both maternal survival and optimal neonatal outcomes.https://www.frontiersin.org/articles/10.3389/frhem.2025.1553336/fullacute promyelocytic leukemiapregnancythird trimestermultidisciplinary approachesperinatal care |
| spellingShingle | Sirichai Puttirangsan B. Prasertkanchana Natnipa Parapob Sirichai Srichairatanakool Thanawat Rattanathammethee Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature Frontiers in Hematology acute promyelocytic leukemia pregnancy third trimester multidisciplinary approaches perinatal care |
| title | Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature |
| title_full | Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature |
| title_fullStr | Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature |
| title_full_unstemmed | Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature |
| title_short | Successful management of acute promyelocytic leukemia in the third trimester of pregnancy: a case report and review of the literature |
| title_sort | successful management of acute promyelocytic leukemia in the third trimester of pregnancy a case report and review of the literature |
| topic | acute promyelocytic leukemia pregnancy third trimester multidisciplinary approaches perinatal care |
| url | https://www.frontiersin.org/articles/10.3389/frhem.2025.1553336/full |
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