CD4 expression controls epidermal stem cell balance
Abstract The balance of stem cell populations is essential for the maintenance, renewal, and repair of the mammalian epidermis. Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed on murine K5+ keratinocytes. Lineage t...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87915-7 |
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| author | Nadine Brandes Heidi Hahn Anja Uhmann |
| author_facet | Nadine Brandes Heidi Hahn Anja Uhmann |
| author_sort | Nadine Brandes |
| collection | DOAJ |
| description | Abstract The balance of stem cell populations is essential for the maintenance, renewal, and repair of the mammalian epidermis. Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed on murine K5+ keratinocytes. Lineage tracing of CD4+ cells reveals that their epidermal progeny has self-renewal abilities and clonogenic potential. The progeny of CD4+ epidermal cells contributes to epidermal renewal and progressively colonizes the interfollicular epidermis and hair follicles with age, thereby developing to all epidermal lineages. Wound healing studies furthermore show that the progeny of CD4+ epidermal cells accumulates at wound sites. Finally, using CD4 knockout mice we demonstrate that CD4 expression is essential for maintaining fast-cycling epidermal stem cells during homeostasis and that CD4 loss mitigates the age-related decline in wound repair capacity. Collectively, our data support the conclusion that CD4 expression is required for long-term maintenance of the epidermal stem cell balance. |
| format | Article |
| id | doaj-art-bc399d3097b54ceebb4d2766d950d628 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bc399d3097b54ceebb4d2766d950d6282025-02-09T12:31:12ZengNature PortfolioScientific Reports2045-23222025-02-0115111410.1038/s41598-025-87915-7CD4 expression controls epidermal stem cell balanceNadine Brandes0Heidi Hahn1Anja Uhmann2Institute of Human Genetics, Tumor Genetics Group, Universitätsmedizin GöttingenInstitute of Human Genetics, Tumor Genetics Group, Universitätsmedizin GöttingenInstitute of Human Genetics, Tumor Genetics Group, Universitätsmedizin GöttingenAbstract The balance of stem cell populations is essential for the maintenance, renewal, and repair of the mammalian epidermis. Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed on murine K5+ keratinocytes. Lineage tracing of CD4+ cells reveals that their epidermal progeny has self-renewal abilities and clonogenic potential. The progeny of CD4+ epidermal cells contributes to epidermal renewal and progressively colonizes the interfollicular epidermis and hair follicles with age, thereby developing to all epidermal lineages. Wound healing studies furthermore show that the progeny of CD4+ epidermal cells accumulates at wound sites. Finally, using CD4 knockout mice we demonstrate that CD4 expression is essential for maintaining fast-cycling epidermal stem cells during homeostasis and that CD4 loss mitigates the age-related decline in wound repair capacity. Collectively, our data support the conclusion that CD4 expression is required for long-term maintenance of the epidermal stem cell balance.https://doi.org/10.1038/s41598-025-87915-7CD4Epidermal stem cellsInterfollicular epidermisInfundibulumWound healing |
| spellingShingle | Nadine Brandes Heidi Hahn Anja Uhmann CD4 expression controls epidermal stem cell balance Scientific Reports CD4 Epidermal stem cells Interfollicular epidermis Infundibulum Wound healing |
| title | CD4 expression controls epidermal stem cell balance |
| title_full | CD4 expression controls epidermal stem cell balance |
| title_fullStr | CD4 expression controls epidermal stem cell balance |
| title_full_unstemmed | CD4 expression controls epidermal stem cell balance |
| title_short | CD4 expression controls epidermal stem cell balance |
| title_sort | cd4 expression controls epidermal stem cell balance |
| topic | CD4 Epidermal stem cells Interfollicular epidermis Infundibulum Wound healing |
| url | https://doi.org/10.1038/s41598-025-87915-7 |
| work_keys_str_mv | AT nadinebrandes cd4expressioncontrolsepidermalstemcellbalance AT heidihahn cd4expressioncontrolsepidermalstemcellbalance AT anjauhmann cd4expressioncontrolsepidermalstemcellbalance |