PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction

PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction

Background and Aims. An increasing number of high-risk patients with coronary heart disease (similar to acute myocardial infarction (AMI)) are using PCSK9 inhibitors. However, whether PCSK9 affects myocardial repair and the molecular mechanism of PCSK9 modulation of immune inflammation after AMI are...

Full description

Saved in:

Bibliographic Details
Main Authors:	Feifei Wang, Min Li, Aidong Zhang, Hairui Li, Can Jiang, Jun Guo
Format:	Article
Language:	English
Published:	Wiley 2022-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2022/7685796
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction
by: Simon Rauterberg, et al.
Published: (2025-01-01)

Left ventricular remodeling in patients with right ventricular myocardial infarction
by: M. T. Beyshenkulov,, et al.
Published: (2015-12-01)

Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction
by: Huan Yao, et al.
Published: (2025-08-01)

Iron in ventricular remodeling and aneurysms post-myocardial infarction
by: Wang Zuoyan, et al.
Published: (2024-12-01)

Electroacupuncture Improves Cardiac Function via Inhibiting Sympathetic Remodeling Mediated by Promoting Macrophage M2 Polarization in Myocardial Infarction Mice
by: Rou Peng, et al.
Published: (2024-01-01)

Matrix metalloprotease 9 and remodeling after myocardial infarction
by: M. G. Shurygin, et al.
Published: (2013-04-01)

Roles of Autophagy, Mitophagy, and Mitochondria in Left Ventricular Remodeling after Myocardial Infarction
by: Xin Zhang, et al.
Published: (2025-03-01)

Inhibitory effect of doxycycline on mmp2/9 and its improvement in cardiac function and left ventricular remodeling after myocardial infarction in rats
by: Fenli ZHANG, et al.
Published: (2025-05-01)

Hydrogel modulate macrophages to promote myocardial repair after myocardial infarction
by: HUANG Huihui, et al.
Published: (2024-05-01)

Effect of PCSK9 Inhibitor on Contrast-Induced Acute Kidney Injury in Patients with Acute Myocardial Infarction Undergoing Intervention Therapy
by: Yu Ma, et al.
Published: (2022-01-01)

Regulatory T cells: a promising new therapeutic target in ventricular remodeling after myocardial infarction
by: Yiran Qin, et al.
Published: (2025-04-01)

LEFT VENTRICULAR REMODELING IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH AND WITHOUT ST SEGMENT ELEVATION
by: N. E. Zakirova, et al.
Published: (2016-05-01)

The Role of MCPIP1 in Macrophage Polarization and Cardiac Function Post‐Myocardial Infarction
by: Xingxu Zhang, et al.
Published: (2025-07-01)

Impact of SGLT2 Inhibitors on Left Ventricular Remodeling in Diabetic Patients with Acute Myocardial Infarction
by: Jun Wan MD, et al.
Published: (2024-12-01)

Influence of secretome from porcine cardiosphere-derived cells on porcine macrophage polarization and their possible implications for cardiac remodeling post-myocardial infarction in vitro
by: M. Pulido, et al.
Published: (2025-06-01)

Tanshinone I promotes angiogenesis and improves ventricular remodeling post-myocardial infarction via ALDH2 signaling-mediated ferroptosis inhibition
by: Feng Zhang, et al.
Published: (2025-06-01)

The role of matrix metalloproteinases in left ventricular remodeling in patients with ST-segment elevation myocardial infarction
by: T. B. Pecherina, et al.
Published: (2019-06-01)

Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization
by: Shaoxi Yan, et al.
Published: (2021-01-01)

Lipid Lowering Treatment and Eligibility for PCSK9 Inhibition in Post-Myocardial Infarction Patients in Italy: Insights from Two Contemporary Nationwide Registries
by: Furio Colivicchi, et al.
Published: (2020-01-01)

Gain of function variants in PCSK9 gene in high risk patients after myocardial infarction with increased lipoprotein (a) values and treated with statins
by: Sabina Ugovšek, et al.
Published: (2025-07-01)

EFFECTS OF ENDOVASCULAR INTERVENTION VS. THROMBOLYSIS ON INTRACARDIAC HEMODYNAMICS AND LEFT VENTRICULAR REMODELLING IN ACUTE MYOCARDIAL INFARCTION
by: M. Kh. Makoeva, et al.
Published: (2012-10-01)

Effects of Exercise Training on Ventricular Remodelling in Patients with Myocardial Infarction: A Systematic Review with Meta-analysis
by: Tejas R Chokshi, et al.
Published: (2025-08-01)

Left ventricular structural heterogeneity and myocardial remodelling
by: A. M. Naidich
Published: (2006-03-01)

Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα
by: Jing Yang, et al.
Published: (2016-01-01)

PCSK9 Inhibitors: The Evolving Future
by: Bijay Mukesh Jeswani, et al.
Published: (2024-11-01)

ECHOCARDIOGRAPHY IN RIGHT VENTRICULAR MYOCARDIAL INFARCTION
by: H. G. Hayrapetyan, et al.
Published: (2013-06-01)

Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice
by: Zequan Yang, et al.
Published: (2020-01-01)

Left ventricular flow kinetics and myocardial deformation following acute infarction: Additional predictive value of cardiac magnetic resonance four-dimensional flow for left ventricular remodeling post-ST-elevation myocardial infarction
by: Christel H. Kamani, et al.
Published: (2025-01-01)

Cholesterol-modulating effects of Korean red ginseng (KRG) targeting PCSK9 in hyperlipidemia
by: Chang Hwan Lee, et al.
Published: (2025-08-01)

Role of Speckle Tracking in the Evaluation of Left Ventricular Remodeling After Streptokinase Infusion in Patients with Acute Anterior Myocardial Infarction
by: Sh. I. Farag, et al.
Published: (2020-12-01)

PCSK9 in T-cell function and the immune response
by: Yuying Wang, et al.
Published: (2024-12-01)

In vivo adeno-associated virus-mediated LDLR/PCSK9 intervention for familial hypercholesterolemia
by: Zeyu Han, et al.
Published: (2025-11-01)

Temporal dynamics of the multi-omic response reveals the modulation of macrophage subsets post-myocardial infarction
by: Yuan Wu, et al.
Published: (2025-07-01)

Early markers of pathological left ventricular remodeling in patients after ST-elevation myocardial infarction according to speckle-tracking echocardiography
by: V. E. Oleinikov, et al.
Published: (2022-07-01)

Pleiotropic Effects of PCSK9 Inhibitors on Cardio-Cerebrovascular Diseases
by: Zhenzhen Li, et al.
Published: (2024-11-01)

The role of macrophage metabolic reprogramming in myocardial infarction
by: ZOU Zicong, et al.
Published: (2024-11-01)

Effects of SGLT2 inhibitors on cardiac autonomic activity and ventricular remodeling in patients with acute myocardial infarction: study protocol for a clinical trial
by: Jun Wan, et al.
Published: (2025-07-01)

Analysis of The Use of PCSK9 Inhibitors in Clinical Practice
by: S. Yu. Volkova, et al.
Published: (2023-03-01)

Current Evidence and Future Directions of PCSK9 Inhibition
by: Jiaqian Xu, et al.
Published: (2021-02-01)

Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice
by: Kay Weipert, et al.
Published: (2025-01-01)