A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies
Aims: Cholinergic dysfunction is key in dementia with Lewy bodies (DLB), and likely to influence the cognitive and psychiatric symptoms of this condition. However, patterns of spatial covariance in DLB in terms of nicotinic acetylcholine receptors (nAChRs) is unknown. In this study we used 123I-5-io...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-06-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472425101312/type/journal_article |
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| author | Judith Harrison Sean Colloby John O’Brien John Paul Taylor |
| author_facet | Judith Harrison Sean Colloby John O’Brien John Paul Taylor |
| author_sort | Judith Harrison |
| collection | DOAJ |
| description | Aims: Cholinergic dysfunction is key in dementia with Lewy bodies (DLB), and likely to influence the cognitive and psychiatric symptoms of this condition. However, patterns of spatial covariance in DLB in terms of nicotinic acetylcholine receptors (nAChRs) is unknown. In this study we used 123I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (1235IA-85380) SPECT (α4β2 nAChR assessment) to investigate the covariance patterns in DLB and their associations with cognition. |
| format | Article |
| id | doaj-art-bc3778559d0044e3b2017bc3fe5a8652 |
| institution | DOAJ |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-bc3778559d0044e3b2017bc3fe5a86522025-08-20T03:15:29ZengCambridge University PressBJPsych Open2056-47242025-06-0111S37S3710.1192/bjo.2025.10131A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy BodiesJudith Harrison0Sean Colloby1John O’Brien2John Paul Taylor31Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom 2Northumbria NHS Healthcare Foundation Trust, Newcastle, United Kingdom1Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom3Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom1Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom 4Central Newcastle Tyne and Wear (CNTW) MHS Foundation Trust, Newcastle, United KingdomAims: Cholinergic dysfunction is key in dementia with Lewy bodies (DLB), and likely to influence the cognitive and psychiatric symptoms of this condition. However, patterns of spatial covariance in DLB in terms of nicotinic acetylcholine receptors (nAChRs) is unknown. In this study we used 123I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (1235IA-85380) SPECT (α4β2 nAChR assessment) to investigate the covariance patterns in DLB and their associations with cognition.https://www.cambridge.org/core/product/identifier/S2056472425101312/type/journal_article |
| spellingShingle | Judith Harrison Sean Colloby John O’Brien John Paul Taylor A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies BJPsych Open |
| title | A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies |
| title_full | A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies |
| title_fullStr | A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies |
| title_full_unstemmed | A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies |
| title_short | A Spatial Covariance 1235IA-85380 SPECT Study of α4β2 Nicotinic Receptors in Dementia with Lewy Bodies |
| title_sort | spatial covariance 1235ia 85380 spect study of α4β2 nicotinic receptors in dementia with lewy bodies |
| url | https://www.cambridge.org/core/product/identifier/S2056472425101312/type/journal_article |
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