Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide‐Spectrum SARS‐CoV‐2, in Healthy Subjects

Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide‐Spectrum SARS‐CoV‐2, in Healthy Subjects

ABSTRACT Severe acute respiratory syndrome caused by the coronavirus (SARS‐CoV‐2) in the COVID‐19 pandemic has highlighted the need for effective treatments, as rapid viral mutations complicate therapeutic development. SNS812, a fully modified inhaled siRNA that targets the conserved RNA‐dependent R...

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Bibliographic Details
Main Authors: Yi‐Chung Chang, Yi‐Fen Chen, Chi‐Fan Yang, Hui‐Ju Ho, Jen Fu Yang, Yuan‐Lin Chou, Ching‐Wen Lin, Pan‐Chyr Yang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Science
Subjects:
nasal spray
SARS‐COV2
siRNAs
Online Access:https://doi.org/10.1111/cts.70202
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