The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability
R-loops, three-stranded RNA-DNA hybrid nucleic acid structures, are recognized for their roles in both physiological and pathological processes. Regulation of R-loops is critical for genome stability as disruption of R-loop homeostasis can lead to aberrant gene expression, replication stress, and DN...
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MDPI AG
2025-06-01
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| Series: | Epigenomes |
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| Online Access: | https://www.mdpi.com/2075-4655/9/2/21 |
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| author | Nicholas Kim Hong Sun |
| author_facet | Nicholas Kim Hong Sun |
| author_sort | Nicholas Kim |
| collection | DOAJ |
| description | R-loops, three-stranded RNA-DNA hybrid nucleic acid structures, are recognized for their roles in both physiological and pathological processes. Regulation of R-loops is critical for genome stability as disruption of R-loop homeostasis can lead to aberrant gene expression, replication stress, and DNA damage. Recent studies suggest that the RNA modification, N6-methyladenosine (m6A), can modify R-loops and the writers, erasers, and readers of m6A are involved in the dynamic regulation of R-loops. Here, we discuss the reported functions of various m6A regulatory proteins in relation to R-loops, highlighting their distinct roles in recognizing and modulating the formation, stability, and resolution of these structures. We further examine the functional implications of m6A and R-loop interaction in human diseases, with a particular emphasis on their roles in cancer. |
| format | Article |
| id | doaj-art-bc32f186bf7240edaef6733f9b54d5d7 |
| institution | Kabale University |
| issn | 2075-4655 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj-art-bc32f186bf7240edaef6733f9b54d5d72025-08-20T03:27:32ZengMDPI AGEpigenomes2075-46552025-06-01922110.3390/epigenomes9020021The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome StabilityNicholas Kim0Hong Sun1Division of Environmental Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10010, USADivision of Environmental Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10010, USAR-loops, three-stranded RNA-DNA hybrid nucleic acid structures, are recognized for their roles in both physiological and pathological processes. Regulation of R-loops is critical for genome stability as disruption of R-loop homeostasis can lead to aberrant gene expression, replication stress, and DNA damage. Recent studies suggest that the RNA modification, N6-methyladenosine (m6A), can modify R-loops and the writers, erasers, and readers of m6A are involved in the dynamic regulation of R-loops. Here, we discuss the reported functions of various m6A regulatory proteins in relation to R-loops, highlighting their distinct roles in recognizing and modulating the formation, stability, and resolution of these structures. We further examine the functional implications of m6A and R-loop interaction in human diseases, with a particular emphasis on their roles in cancer.https://www.mdpi.com/2075-4655/9/2/21R-loopsm6A RNA modificationgenome stabilityDNA damage |
| spellingShingle | Nicholas Kim Hong Sun The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability Epigenomes R-loops m6A RNA modification genome stability DNA damage |
| title | The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability |
| title_full | The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability |
| title_fullStr | The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability |
| title_full_unstemmed | The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability |
| title_short | The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability |
| title_sort | dynamic interactions of m6a modification and r loops implications for genome stability |
| topic | R-loops m6A RNA modification genome stability DNA damage |
| url | https://www.mdpi.com/2075-4655/9/2/21 |
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