Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers
The present study aims to evaluate the effects of Gallus epidermal growth factor (gEGF) on growth performance, immune function, intestinal barrier, and the inflammatory response in broilers. A total of 192 one-day-old Xianju broilers were randomly divided into 4 groups, each consisting of 8 replicat...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Applied Animal Research |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09712119.2025.2470215 |
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| author | Yubiao Jia Qiuming Huang Rui Song Jianyong Zhou Chuansong Sun Jianjun Lu |
| author_facet | Yubiao Jia Qiuming Huang Rui Song Jianyong Zhou Chuansong Sun Jianjun Lu |
| author_sort | Yubiao Jia |
| collection | DOAJ |
| description | The present study aims to evaluate the effects of Gallus epidermal growth factor (gEGF) on growth performance, immune function, intestinal barrier, and the inflammatory response in broilers. A total of 192 one-day-old Xianju broilers were randomly divided into 4 groups, each consisting of 8 replicates with 6 broilers per replicate. The control group was fed a basal diet, while the experimental groups received the basal diet supplemented with 4, 8, and 12 ng/kg gEGF, respectively. The results demonstrated that 8 ng/kg gEGF significantly improved the average daily body weight gain of the broilers, increased intestinal goblet cell density, and ameliorated intestinal morphology. Supplementation with gEGF promoted serum immunoglobulin A (IgA), IgM, IgG, and lysozyme secretion, as well as increased immune organ indices, including the thymus, spleen, and bursa. Additionally, dietary supplementation with gEGF significantly upregulated the mRNA expression levels of MUC2, TRAF6, and TGF-β1 in the trachea, Harderian gland, and cecal tonsil. Furthermore, gEGF enhanced the jejunal mucosa mRNA expression levels of MUC2, IL-13, and TCR, while downregulating the mRNA expression of IL-1β, IL-6, and TNF-α. In conclusion, dietary supplementation with gEGF promoted growth performance in broilers by ameliorating intestinal morphology, enhancing immune function, strengthening gut barrier, and inhibiting inflammatory response. |
| format | Article |
| id | doaj-art-bc270396bc8d424cb6a9d175a17dbfc5 |
| institution | OA Journals |
| issn | 0971-2119 0974-1844 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Applied Animal Research |
| spelling | doaj-art-bc270396bc8d424cb6a9d175a17dbfc52025-08-20T02:30:28ZengTaylor & Francis GroupJournal of Applied Animal Research0971-21190974-18442025-12-0153110.1080/09712119.2025.2470215Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilersYubiao Jia0Qiuming Huang1Rui Song2Jianyong Zhou3Chuansong Sun4Jianjun Lu5Key Laboratory for Animal Molecular Nutrition of Ministry of Education, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaKey Laboratory for Animal Molecular Nutrition of Ministry of Education, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaKey Laboratory for Animal Molecular Nutrition of Ministry of Education, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaKey Laboratory for Animal Molecular Nutrition of Ministry of Education, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaKey Laboratory for Animal Molecular Nutrition of Ministry of Education, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaKey Laboratory for Animal Molecular Nutrition of Ministry of Education, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, People’s Republic of ChinaThe present study aims to evaluate the effects of Gallus epidermal growth factor (gEGF) on growth performance, immune function, intestinal barrier, and the inflammatory response in broilers. A total of 192 one-day-old Xianju broilers were randomly divided into 4 groups, each consisting of 8 replicates with 6 broilers per replicate. The control group was fed a basal diet, while the experimental groups received the basal diet supplemented with 4, 8, and 12 ng/kg gEGF, respectively. The results demonstrated that 8 ng/kg gEGF significantly improved the average daily body weight gain of the broilers, increased intestinal goblet cell density, and ameliorated intestinal morphology. Supplementation with gEGF promoted serum immunoglobulin A (IgA), IgM, IgG, and lysozyme secretion, as well as increased immune organ indices, including the thymus, spleen, and bursa. Additionally, dietary supplementation with gEGF significantly upregulated the mRNA expression levels of MUC2, TRAF6, and TGF-β1 in the trachea, Harderian gland, and cecal tonsil. Furthermore, gEGF enhanced the jejunal mucosa mRNA expression levels of MUC2, IL-13, and TCR, while downregulating the mRNA expression of IL-1β, IL-6, and TNF-α. In conclusion, dietary supplementation with gEGF promoted growth performance in broilers by ameliorating intestinal morphology, enhancing immune function, strengthening gut barrier, and inhibiting inflammatory response.https://www.tandfonline.com/doi/10.1080/09712119.2025.2470215Gallus epidermal growth factorbroilergrowth performanceimmunityintestinal morphology |
| spellingShingle | Yubiao Jia Qiuming Huang Rui Song Jianyong Zhou Chuansong Sun Jianjun Lu Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers Journal of Applied Animal Research Gallus epidermal growth factor broiler growth performance immunity intestinal morphology |
| title | Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers |
| title_full | Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers |
| title_fullStr | Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers |
| title_full_unstemmed | Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers |
| title_short | Effects of Gallus epidermal growth factor on immune function and intestinal development in male broilers |
| title_sort | effects of gallus epidermal growth factor on immune function and intestinal development in male broilers |
| topic | Gallus epidermal growth factor broiler growth performance immunity intestinal morphology |
| url | https://www.tandfonline.com/doi/10.1080/09712119.2025.2470215 |
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