Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics

Comparison of interpretation of acute lymphoblastic leukemia (ALL) flow cytometric diagnostics data was the aim of the study. Immunophenotyping data obtained from 10 patients with ALL were analysed separately in 26 laboratories from Russian Federation and Kazahstan. Results comparison showed four ma...

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Main Authors: A. M. Popov, T. U. Verzhbitskaya, E. E. Zueva, O. V. Anan’eva, E. V. Babenko, L. V. Baydun, E. A. Belyakova, E. V. Boyakova, O. G. Bortnikova, M. V. Gorchakova, L. Yu. Grivtsova, E. N. Grinkevich, Yu. V. Davydova, E. I. Zakhar’ko, O. I. Illarionova, N. M. Kaprano, E. A. Koroleva, S. A. Kochengina, E. G. Kuz’mina, E. A. Kustova, T. A. Makarova, Yu. V. Mirolyubova, O. E. Murashkina, T. Yu. Mushkarina, E. S. Nisheva, I. A. Novikova, E. Yu. Osipova, G. E. Pluzhnikova, M. E. Pochtar, N. V. Pronkina, E. V. Rusanova, E. B. Rybkina, O. V. Seliverstova, N. N. Tupitsin, G. I. Uleyskaya, N. T. Urazalieva, L. G. Fechina, O. V. Khoroshikh, O. E. Tsareva, L. A. Shchekina, S. A. Plyasunova, S. A. Lugovskaya
Format: Article
Language:Russian
Published: ABV-press 2016-10-01
Series:Онкогематология
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Online Access:https://oncohematology.abvpress.ru/ongm/article/view/208
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author A. M. Popov
T. U. Verzhbitskaya
E. E. Zueva
O. V. Anan’eva
E. V. Babenko
L. V. Baydun
E. A. Belyakova
E. V. Boyakova
O. G. Bortnikova
M. V. Gorchakova
L. Yu. Grivtsova
E. N. Grinkevich
Yu. V. Davydova
E. I. Zakhar’ko
O. I. Illarionova
N. M. Kaprano
E. A. Koroleva
S. A. Kochengina
E. G. Kuz’mina
E. A. Kustova
T. A. Makarova
Yu. V. Mirolyubova
O. E. Murashkina
T. Yu. Mushkarina
E. S. Nisheva
I. A. Novikova
E. Yu. Osipova
G. E. Pluzhnikova
M. E. Pochtar
N. V. Pronkina
E. V. Rusanova
E. B. Rybkina
O. V. Seliverstova
N. N. Tupitsin
G. I. Uleyskaya
N. T. Urazalieva
L. G. Fechina
O. V. Khoroshikh
O. E. Tsareva
L. A. Shchekina
S. A. Plyasunova
S. A. Lugovskaya
author_facet A. M. Popov
T. U. Verzhbitskaya
E. E. Zueva
O. V. Anan’eva
E. V. Babenko
L. V. Baydun
E. A. Belyakova
E. V. Boyakova
O. G. Bortnikova
M. V. Gorchakova
L. Yu. Grivtsova
E. N. Grinkevich
Yu. V. Davydova
E. I. Zakhar’ko
O. I. Illarionova
N. M. Kaprano
E. A. Koroleva
S. A. Kochengina
E. G. Kuz’mina
E. A. Kustova
T. A. Makarova
Yu. V. Mirolyubova
O. E. Murashkina
T. Yu. Mushkarina
E. S. Nisheva
I. A. Novikova
E. Yu. Osipova
G. E. Pluzhnikova
M. E. Pochtar
N. V. Pronkina
E. V. Rusanova
E. B. Rybkina
O. V. Seliverstova
N. N. Tupitsin
G. I. Uleyskaya
N. T. Urazalieva
L. G. Fechina
O. V. Khoroshikh
O. E. Tsareva
L. A. Shchekina
S. A. Plyasunova
S. A. Lugovskaya
author_sort A. M. Popov
collection DOAJ
description Comparison of interpretation of acute lymphoblastic leukemia (ALL) flow cytometric diagnostics data was the aim of the study. Immunophenotyping data obtained from 10 patients with ALL were analysed separately in 26 laboratories from Russian Federation and Kazahstan. Results comparison showed four main type of discordance: B-lineage ALL diagnostics during heavy bone marrow regeneration, great variability of T-ALL interpretation, complexity of ambiguous lineage acute leukemia and, finally, very different report types, unique for each laboratory. All these problems are the serious obstacles for standardization of flow cytometric ALL diagnostics in multicenter setting. Continuation of similar QC rounds following by consecutive discussions with further development of consensus diagnostic algorithm could be the first step for standardization of ALL immunophenotyping in Russian Federation and CIS countries.
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series Онкогематология
spelling doaj-art-bc25e5d62d554850b622e9652ee965232025-08-20T04:00:13ZrusABV-pressОнкогематология1818-83462413-40232016-10-01113687510.17650/1818-8346-2016-11-3-68-75209Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnosticsA. M. Popov0T. U. Verzhbitskaya1E. E. Zueva2O. V. Anan’eva3E. V. Babenko4L. V. Baydun5E. A. Belyakova6E. V. Boyakova7O. G. Bortnikova8M. V. Gorchakova9L. Yu. Grivtsova10E. N. Grinkevich11Yu. V. Davydova12E. I. Zakhar’ko13O. I. Illarionova14N. M. Kaprano15E. A. Koroleva16S. A. Kochengina17E. G. Kuz’mina18E. A. Kustova19T. A. Makarova20Yu. V. Mirolyubova21O. E. Murashkina22T. Yu. Mushkarina23E. S. Nisheva24I. A. Novikova25E. Yu. Osipova26G. E. Pluzhnikova27M. E. Pochtar28N. V. Pronkina29E. V. Rusanova30E. B. Rybkina31O. V. Seliverstova32N. N. Tupitsin33G. I. Uleyskaya34N. T. Urazalieva35L. G. Fechina36O. V. Khoroshikh37O. E. Tsareva38L. A. Shchekina39S. A. Plyasunova40S. A. Lugovskaya41Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Ministry of Health of RussiaRegional Children Clinical Hospital No 1Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Laboratory of Clinical Immunology and Molecular Diagnostics, Department of Laboratory Diagnostics, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaTyumen State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, R. M. Gorbacheva Research Institute of Pediatric Oncology, Hematology and TransplantologyRussian Children Clinical Hospital, Ministry of Health of RussiaNorth-Western State Medical University named after I.I. Mechnikov, Ministry of Health of RussiaBlood Transfusion Station of the Moscow Healthcare DepartmentRegional Children Clinical HospitalLaboratory of Clinical Immunology and Molecular Diagnostics, Department of Laboratory Diagnostics, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaN.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaNizhnevartovsk Regional Children Clinical HospitalNizhnevartovsk Regional Children Clinical HospitalCentral Clinical Diagnostic Laboratory with a Group of Hemostasis Disorders, National Research Center for Hematology, Ministry of Health of RussiaFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Ministry of Health of RussiaScientific Clinical Laboratory of Immunophenotyping of Blood Cells and Bone Marrow, National Research Center for Hematology, Ministry of Health of RussiaDiagnostic Center of the Altai RegionChelyabinsk Regional Children Clinical HospitalA.F. Tsyb Medical Radiological Research Center – Branch of the National Medical Radiological Research Center, Ministry of Health of RussiaResearch Center of Pediatrics and Pediatric SurgeryChildren City Hospital No 1ФГБУ «Северо-Западный федеральный медицинский исследовательский центр» Минздрава РоссииChildren Regional Clinical HospitalA.F. Tsyb Medical Radiological Research Center – Branch of the National Medical Radiological Research Center, Ministry of Health of RussiaChildren City Hospital No 1Rostov Research Institute of Oncology, Ministry of Health of RussiaFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Ministry of Health of RussiaRegional Children Clinical HospitalDepartment of Clinical Laboratory Diagnostics, Russian Medical Academy of Postgraduate Education, Ministry of Health of RussiaClinic of Immunopathology, Research Institute of Fundamental and Clinical ImmunologyLaboratory of Clinical Immunology and Molecular Diagnostics, Department of Laboratory Diagnostics, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaCentral Clinical Diagnostic Laboratory with a Group of Hemostasis Disorders, National Research Center for Hematology, Ministry of Health of RussiaBlood Transfusion Station of the Moscow Healthcare DepartmentN.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaCity Clinical Hospital No 31Research Center of Pediatrics and Pediatric SurgeryRegional Children Clinical Hospital No 1Irkutsk the Badge of Honor Order Regional Clinical HospitalSaratov State Medical University named after V.I. Razumovsky, Ministry of Health of RussiaCity Clinical Hospital No 31Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Ministry of Health of RussiaDepartment of Clinical Laboratory Diagnostics, Russian Medical Academy of Postgraduate Education, Ministry of Health of RussiaComparison of interpretation of acute lymphoblastic leukemia (ALL) flow cytometric diagnostics data was the aim of the study. Immunophenotyping data obtained from 10 patients with ALL were analysed separately in 26 laboratories from Russian Federation and Kazahstan. Results comparison showed four main type of discordance: B-lineage ALL diagnostics during heavy bone marrow regeneration, great variability of T-ALL interpretation, complexity of ambiguous lineage acute leukemia and, finally, very different report types, unique for each laboratory. All these problems are the serious obstacles for standardization of flow cytometric ALL diagnostics in multicenter setting. Continuation of similar QC rounds following by consecutive discussions with further development of consensus diagnostic algorithm could be the first step for standardization of ALL immunophenotyping in Russian Federation and CIS countries.https://oncohematology.abvpress.ru/ongm/article/view/208flow cytometryacute lymphoblastic leukemiastandardization
spellingShingle A. M. Popov
T. U. Verzhbitskaya
E. E. Zueva
O. V. Anan’eva
E. V. Babenko
L. V. Baydun
E. A. Belyakova
E. V. Boyakova
O. G. Bortnikova
M. V. Gorchakova
L. Yu. Grivtsova
E. N. Grinkevich
Yu. V. Davydova
E. I. Zakhar’ko
O. I. Illarionova
N. M. Kaprano
E. A. Koroleva
S. A. Kochengina
E. G. Kuz’mina
E. A. Kustova
T. A. Makarova
Yu. V. Mirolyubova
O. E. Murashkina
T. Yu. Mushkarina
E. S. Nisheva
I. A. Novikova
E. Yu. Osipova
G. E. Pluzhnikova
M. E. Pochtar
N. V. Pronkina
E. V. Rusanova
E. B. Rybkina
O. V. Seliverstova
N. N. Tupitsin
G. I. Uleyskaya
N. T. Urazalieva
L. G. Fechina
O. V. Khoroshikh
O. E. Tsareva
L. A. Shchekina
S. A. Plyasunova
S. A. Lugovskaya
Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
Онкогематология
flow cytometry
acute lymphoblastic leukemia
standardization
title Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
title_full Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
title_fullStr Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
title_full_unstemmed Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
title_short Results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
title_sort results of external quality control study in flow cytometric acute lymphoblastic leukemia diagnostics
topic flow cytometry
acute lymphoblastic leukemia
standardization
url https://oncohematology.abvpress.ru/ongm/article/view/208
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