Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice
Background Individuals experience varying levels of fatigue and stamina. Moringa oleifera Lam. Seed extract relieves fatigue due to its high levels of antioxidants and glucosinolate glucomoringin, which reduces intracellular oxidative stress. Objectives This study aimed to determine the effectiv...
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School of Veterinary Medicine and Biomedical Sciences, IPB University
2025-07-01
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| Series: | Current Biomedicine |
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| Online Access: | https://journal.ipb.ac.id/index.php/currbiomed/article/view/64242 |
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| author | Hanifati Husna Andriyanto Andriyanto Wasmen Manalu Kusdiantoro Mohamad |
| author_facet | Hanifati Husna Andriyanto Andriyanto Wasmen Manalu Kusdiantoro Mohamad |
| author_sort | Hanifati Husna |
| collection | DOAJ |
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Background Individuals experience varying levels of fatigue and stamina. Moringa oleifera Lam. Seed extract relieves fatigue due to its high levels of antioxidants and glucosinolate glucomoringin, which reduces intracellular oxidative stress.
Objectives This study aimed to determine the effectiveness of infusion of M. oleifera seed as a stamina stimulator in mice.
Methods This experiment used 25 male mice divided into five groups (five mice in each group), consisting of M. oleifera seed infusion at doses of 0, 1, 3, and 5 g/kg BW as the negative control and treatment groups, and caffeine at a dose of 6.5 mg/kg BW as the positive control group. Stamina effectiveness was evaluated using a swimming endurance test that measured swimming duration and physiological parameters every 15 min for 2 h after administration. Data were analyzed using analysis of variance (ANOVA) followed by Tukey’s test.
Results M. oleifera seed infusion at a dose of 3 g/kg BW had the shortest swimming duration difference (Δ) value, with no difference compared to the 5 g/kg BW and caffeine groups, but was significantly different (P<0.05) compared to the 0 and 1 g/kg BW groups. M. oleifera seed infusion at a dose of 3 g/kg BW also showed a lower delta value for body surface temperature and heartbeat rate compared to the negative control, and a lower delta value for the respiratory rate compared to the 5 g/kg BW group.
Conclusion M. oleifera seed infusion potentially maintains stamina performance in mice at a dose of 3 g/kg BW.
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| format | Article |
| id | doaj-art-bc1f6de829f540aba522b084c287e808 |
| institution | DOAJ |
| issn | 2962-8490 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | School of Veterinary Medicine and Biomedical Sciences, IPB University |
| record_format | Article |
| series | Current Biomedicine |
| spelling | doaj-art-bc1f6de829f540aba522b084c287e8082025-08-20T02:43:12ZengSchool of Veterinary Medicine and Biomedical Sciences, IPB UniversityCurrent Biomedicine2962-84902025-07-013210.29244/currbiomed.3.2.67Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice Hanifati Husna0 Andriyanto Andriyanto1 Wasmen Manalu2 Kusdiantoro Mohamad3Study Program of Veterinary Medicine, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, IndonesiaDivision of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, IndonesiaDivision of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, IndonesiaDivision of Anatomy, Histology, and Embryology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia Background Individuals experience varying levels of fatigue and stamina. Moringa oleifera Lam. Seed extract relieves fatigue due to its high levels of antioxidants and glucosinolate glucomoringin, which reduces intracellular oxidative stress. Objectives This study aimed to determine the effectiveness of infusion of M. oleifera seed as a stamina stimulator in mice. Methods This experiment used 25 male mice divided into five groups (five mice in each group), consisting of M. oleifera seed infusion at doses of 0, 1, 3, and 5 g/kg BW as the negative control and treatment groups, and caffeine at a dose of 6.5 mg/kg BW as the positive control group. Stamina effectiveness was evaluated using a swimming endurance test that measured swimming duration and physiological parameters every 15 min for 2 h after administration. Data were analyzed using analysis of variance (ANOVA) followed by Tukey’s test. Results M. oleifera seed infusion at a dose of 3 g/kg BW had the shortest swimming duration difference (Δ) value, with no difference compared to the 5 g/kg BW and caffeine groups, but was significantly different (P<0.05) compared to the 0 and 1 g/kg BW groups. M. oleifera seed infusion at a dose of 3 g/kg BW also showed a lower delta value for body surface temperature and heartbeat rate compared to the negative control, and a lower delta value for the respiratory rate compared to the 5 g/kg BW group. Conclusion M. oleifera seed infusion potentially maintains stamina performance in mice at a dose of 3 g/kg BW. https://journal.ipb.ac.id/index.php/currbiomed/article/view/64242anti-fatigueinfusionMoringa oleiferastamina performancemice |
| spellingShingle | Hanifati Husna Andriyanto Andriyanto Wasmen Manalu Kusdiantoro Mohamad Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice Current Biomedicine anti-fatigue infusion Moringa oleifera stamina performance mice |
| title | Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice |
| title_full | Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice |
| title_fullStr | Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice |
| title_full_unstemmed | Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice |
| title_short | Effect of moringa seed (Moringa oleifera Lam.) infusion on stamina performance in male mice |
| title_sort | effect of moringa seed moringa oleifera lam infusion on stamina performance in male mice |
| topic | anti-fatigue infusion Moringa oleifera stamina performance mice |
| url | https://journal.ipb.ac.id/index.php/currbiomed/article/view/64242 |
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