Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis

Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis

Abstract Voltage-gated potassium channels, Kv3.1, Kv3.2, Kv3.3, and Kv3.4, facilitate rapid repolarization and shape action potentials, which are crucial to maintaining high-frequency firing. Little is known about the expression and function of Kv3 channels in skeletal muscle. We show that these cha...

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Main Authors: Manuela Marabita, Caterina Marchioretti, Aishwarya Aravamudhan, Simona Zito, Antonella Falconieri, Emanuela Zuccaro, Roberta Andreotti, Lisa Gambarotto, Samuele Metti, Marika Tonellato, Valentina Adami, Kyung Ho Park, Martin J. Gunthorpe, Charles H. Large, Agostino Marasco, Sara Vianello, Jessica Rosati, Elisa Belluzzi, Assunta Pozzuoli, Carlo Biz, Pietro Ruggieri, Manuela Basso, Angelo Poletti, Giuseppe Alvaro, Gianni Sorarù, Paolo Bonaldo, Ornella Rossetto, Nadia Pilati, Maria Pennuto
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-025-02067-z
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