Acute Kidney Injury in Lymphoma: A Single Centre Experience
Background. Acute kidney injury (AKI) is a common but least studied complication of lymphoma. Objective. To determine the frequency and predictors of AKI in lymphoma and to study the impact of AKI on hospital stay and mortality. Methods. Retrospective review of medical records of hospitalized lympho...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/272961 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567825820024832 |
|---|---|
| author | Muhammad Abdul Mabood Khalil Hira Latif Abdur Rehman Waqar Uddin Kashif Safia Awan Zarghona Khalil Uziar Mushtaq Maria Ahmad Muhammad Ashhad Ullah Khalil Manickam Ranga Sami Jackson Tan |
| author_facet | Muhammad Abdul Mabood Khalil Hira Latif Abdur Rehman Waqar Uddin Kashif Safia Awan Zarghona Khalil Uziar Mushtaq Maria Ahmad Muhammad Ashhad Ullah Khalil Manickam Ranga Sami Jackson Tan |
| author_sort | Muhammad Abdul Mabood Khalil |
| collection | DOAJ |
| description | Background. Acute kidney injury (AKI) is a common but least studied complication of lymphoma. Objective. To determine the frequency and predictors of AKI in lymphoma and to study the impact of AKI on hospital stay and mortality. Methods. Retrospective review of medical records of hospitalized lymphoma patients aged ≥14 years between January 2008 and December 2011 was done. Results. Out of 365 patients, AKI was present in 31.8% (116/365). Multivariate logistic regression analysis showed that independent predictors for AKI included sepsis (odds ratio (OR) 3.76; 95% CI 1.83–7.72), aminoglycosides (OR 4.75; 95% CI 1.15–19.52), diuretics (OR 2.96; 95% CI 1.31–6.69), tumor lysis syndrome (OR 3.85; 95% CI 1.54–9.59), and R-CVP regimen (OR 4.70; 95% CI 1.20–18.36). AKI stages 2 and 3 was associated with increased hospital stay (OR 2.01; 95% CI 1.19–3.40). Conclusion. AKI was significantly associated with sepsis, aminoglycoside, diuretics, presence of tumor lysis syndrome, and use of R-CVP regimen. Presence of AKIN (Acute Kidney Injury Network) stages 2 and 3 AKI had increased hospital stay. AKI was also associated with increased mortality. |
| format | Article |
| id | doaj-art-bc1a5ee0ac0e4246bb8c6b05154f838e |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-bc1a5ee0ac0e4246bb8c6b05154f838e2025-02-03T01:00:25ZengWileyInternational Journal of Nephrology2090-214X2090-21582014-01-01201410.1155/2014/272961272961Acute Kidney Injury in Lymphoma: A Single Centre ExperienceMuhammad Abdul Mabood Khalil0Hira Latif1Abdur Rehman2Waqar Uddin Kashif3Safia Awan4Zarghona Khalil5Uziar Mushtaq6Maria Ahmad7Muhammad Ashhad Ullah Khalil8Manickam Ranga Sami9Jackson Tan10Section of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanSection of Nephrology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, PakistanDepartment of Medicine, Khyber Teaching Hospital, Peshawar 25000, PakistanDepartment of Nephrology, SSB Hospital, Kuala Belait KA1131, Brunei DarussalamDepartment of Nephrology, RIPAS Hospital, Bandar Seri Begawan BA1710, Brunei DarussalamBackground. Acute kidney injury (AKI) is a common but least studied complication of lymphoma. Objective. To determine the frequency and predictors of AKI in lymphoma and to study the impact of AKI on hospital stay and mortality. Methods. Retrospective review of medical records of hospitalized lymphoma patients aged ≥14 years between January 2008 and December 2011 was done. Results. Out of 365 patients, AKI was present in 31.8% (116/365). Multivariate logistic regression analysis showed that independent predictors for AKI included sepsis (odds ratio (OR) 3.76; 95% CI 1.83–7.72), aminoglycosides (OR 4.75; 95% CI 1.15–19.52), diuretics (OR 2.96; 95% CI 1.31–6.69), tumor lysis syndrome (OR 3.85; 95% CI 1.54–9.59), and R-CVP regimen (OR 4.70; 95% CI 1.20–18.36). AKI stages 2 and 3 was associated with increased hospital stay (OR 2.01; 95% CI 1.19–3.40). Conclusion. AKI was significantly associated with sepsis, aminoglycoside, diuretics, presence of tumor lysis syndrome, and use of R-CVP regimen. Presence of AKIN (Acute Kidney Injury Network) stages 2 and 3 AKI had increased hospital stay. AKI was also associated with increased mortality.http://dx.doi.org/10.1155/2014/272961 |
| spellingShingle | Muhammad Abdul Mabood Khalil Hira Latif Abdur Rehman Waqar Uddin Kashif Safia Awan Zarghona Khalil Uziar Mushtaq Maria Ahmad Muhammad Ashhad Ullah Khalil Manickam Ranga Sami Jackson Tan Acute Kidney Injury in Lymphoma: A Single Centre Experience International Journal of Nephrology |
| title | Acute Kidney Injury in Lymphoma: A Single Centre Experience |
| title_full | Acute Kidney Injury in Lymphoma: A Single Centre Experience |
| title_fullStr | Acute Kidney Injury in Lymphoma: A Single Centre Experience |
| title_full_unstemmed | Acute Kidney Injury in Lymphoma: A Single Centre Experience |
| title_short | Acute Kidney Injury in Lymphoma: A Single Centre Experience |
| title_sort | acute kidney injury in lymphoma a single centre experience |
| url | http://dx.doi.org/10.1155/2014/272961 |
| work_keys_str_mv | AT muhammadabdulmaboodkhalil acutekidneyinjuryinlymphomaasinglecentreexperience AT hiralatif acutekidneyinjuryinlymphomaasinglecentreexperience AT abdurrehman acutekidneyinjuryinlymphomaasinglecentreexperience AT waqaruddinkashif acutekidneyinjuryinlymphomaasinglecentreexperience AT safiaawan acutekidneyinjuryinlymphomaasinglecentreexperience AT zarghonakhalil acutekidneyinjuryinlymphomaasinglecentreexperience AT uziarmushtaq acutekidneyinjuryinlymphomaasinglecentreexperience AT mariaahmad acutekidneyinjuryinlymphomaasinglecentreexperience AT muhammadashhadullahkhalil acutekidneyinjuryinlymphomaasinglecentreexperience AT manickamrangasami acutekidneyinjuryinlymphomaasinglecentreexperience AT jacksontan acutekidneyinjuryinlymphomaasinglecentreexperience |