Estimating Cancer Penetrance in Carriers of BRCA2 Pathogenic Variants Using Cancer‐Specific Polygenic Scores

Estimating Cancer Penetrance in Carriers of BRCA2 Pathogenic Variants Using Cancer‐Specific Polygenic Scores

ABSTRACT Introduction BRCA2 is a causal gene for hereditary breast and ovarian cancer (HBOC) syndrome. However, its association with other cancers and interplay with polygenic scores (PGS) remains unclear. Methods An observational cohort study for the diagnosis of various cancers in the UK Biobank (...

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Main Authors: Brendan Prassas, Zhuqing Shi, Huy Tran, Jun Wei, Chi‐Hsiung Wang, Andrew S. Rifkin, Annabelle Ashworth, S. Lilly Zheng, Ashley J. Mulford, Alan R. Sanders, Catherine E. Pesce, Brian T. Helfand, Henry M. Dunnenberger, David Duggan, Peter J. Hulick, Allison DePersia, Jianfeng Xu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Cancer Medicine
Subjects:
BRCA2
breast cancer (female and male)
hereditary breast and ovarian cancer syndrome (HBOC)
liver cancer
lung cancer
oral cancer
Online Access:https://doi.org/10.1002/cam4.70990
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https://doi.org/10.1002/cam4.70990

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