Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients
Objective To study the association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis(MHD) patients. Methods The clinical data of 138 patients receiving MHD during January 2016 to January 2017 in Hemodialysis Center of our hospital were collected. Patients were...
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Editorial Department of Journal of Clinical Nephrology
2019-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| _version_ | 1849728785765629952 |
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| author | CHENG Jin WANG Wei LIU Guo-xiang |
| author_facet | CHENG Jin WANG Wei LIU Guo-xiang |
| author_sort | CHENG Jin |
| collection | DOAJ |
| description | Objective To study the association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis(MHD) patients. Methods The clinical data of 138 patients receiving MHD during January 2016 to January 2017 in Hemodialysis Center of our hospital were collected. Patients were examined for serum sclerostin levels and related clinical data, CT-assisted detection of coronary artery calcification score. Multivariate logistic regression was used to analyze the correlation between sclerostin and coronary artery calcification in MHD patients. The ROC curve was used to analyze the diagnostic value of sclerostin in MHD patients. Results Logistic regression analysis showed that sclerostin was an independent risk factor for coronary artery calcification(OR=1.362, 95% CI=1.073-1.724, P=0.032). The analysis on the ROC curve of sclerostin for coronary artery calcifications revealed AUC=0.826, 95% CI=0.759-0.892, P=0.000. The diagnostic value of slerostin was 47.71 ng/L, the diagnostic sensitivity was 0.607, and the specificity was 0.938. Conclusions The high concentration of sclerostin is an independent risk factor for coronary artery calcification in MHD patients. It is significant for sclerostin to diagnose coronary artery calcification in MHD patients. |
| format | Article |
| id | doaj-art-bc10fe638d80459d96fec029355f7520 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2019-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-bc10fe638d80459d96fec029355f75202025-08-20T03:09:25ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902019-01-01869057913868Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patientsCHENG JinWANG WeiLIU Guo-xiangObjective To study the association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis(MHD) patients. Methods The clinical data of 138 patients receiving MHD during January 2016 to January 2017 in Hemodialysis Center of our hospital were collected. Patients were examined for serum sclerostin levels and related clinical data, CT-assisted detection of coronary artery calcification score. Multivariate logistic regression was used to analyze the correlation between sclerostin and coronary artery calcification in MHD patients. The ROC curve was used to analyze the diagnostic value of sclerostin in MHD patients. Results Logistic regression analysis showed that sclerostin was an independent risk factor for coronary artery calcification(OR=1.362, 95% CI=1.073-1.724, P=0.032). The analysis on the ROC curve of sclerostin for coronary artery calcifications revealed AUC=0.826, 95% CI=0.759-0.892, P=0.000. The diagnostic value of slerostin was 47.71 ng/L, the diagnostic sensitivity was 0.607, and the specificity was 0.938. Conclusions The high concentration of sclerostin is an independent risk factor for coronary artery calcification in MHD patients. It is significant for sclerostin to diagnose coronary artery calcification in MHD patients.http://www.lcszb.com/thesisDetails?columnId=57913868&Fpath=home&index=0SclerostinMaintenance hemodialysisCoronary artery calcification |
| spellingShingle | CHENG Jin WANG Wei LIU Guo-xiang Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients Linchuang shenzangbing zazhi Sclerostin Maintenance hemodialysis Coronary artery calcification |
| title | Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients |
| title_full | Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients |
| title_fullStr | Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients |
| title_full_unstemmed | Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients |
| title_short | Association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients |
| title_sort | association of serum sclerostin level with coronary artery calcification in maintenance hemodialysis patients |
| topic | Sclerostin Maintenance hemodialysis Coronary artery calcification |
| url | http://www.lcszb.com/thesisDetails?columnId=57913868&Fpath=home&index=0 |
| work_keys_str_mv | AT chengjin associationofserumsclerostinlevelwithcoronaryarterycalcificationinmaintenancehemodialysispatients AT wangwei associationofserumsclerostinlevelwithcoronaryarterycalcificationinmaintenancehemodialysispatients AT liuguoxiang associationofserumsclerostinlevelwithcoronaryarterycalcificationinmaintenancehemodialysispatients |