FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION
A retrospective cohort study was performed to reveal risk factors for fluoroquinolone resistance in M. tuberculosis during treatment of 463 patients with multidrug-resistant (MDR) tuberculosis (TB) in the Novosibirsk Region. The factors associated with an increased risk were the extent of a TB proce...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2014-05-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/72 |
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| author | Ya. R. Batyrshina T. I. Petrenko |
| author_facet | Ya. R. Batyrshina T. I. Petrenko |
| author_sort | Ya. R. Batyrshina |
| collection | DOAJ |
| description | A retrospective cohort study was performed to reveal risk factors for fluoroquinolone resistance in M. tuberculosis during treatment of 463 patients with multidrug-resistant (MDR) tuberculosis (TB) in the Novosibirsk Region. The factors associated with an increased risk were the extent of a TB process within > 2 lung segments (OR 1.39; 95% CI, 0.87-2.21), abundant bacterial excretion (OR 2.32; 95% CI, 1.54-3.5), primary aminoglycoside/capreomycin resistance in M. tuberculosis (OR 3.35; 95% CI, 1.80-6.24), concomitant alcohol/drug dependence (OR 1.46; 95 CI, 0.76-2.80), renal dysfunction (OR 4.60; 95% CI, 1.28-16.51), deviations from the standard polychemotherapy of MDR TB (OR 3.17; 95% CI, 1.58-6.34), fluoroquinolones used in doses lower than the recommended one (OR 5.23; 95% CI, 2.27-12.10), discontinuation of a polychemotherapy cycle (OR 5.70; 95% CI, 2.97-10.93), rural residence (OR 2.0; 95% CI: 1.14-3.51), and being in prison (OR 2.0; 95% CI, 1.14-3.51). Resection surgery (OR 0.48; 95% CI, 0.2-1.13), in-hospital intensive-phase polychemotherapy (OR 0.43; 95 CI, 0.27-0.63), and parenteral administration of anti-TB drugs (OR 0.40; 95% CI, 0.18-0.86) were associated with risk reduction. |
| format | Article |
| id | doaj-art-bc0d04fd5adb401f8c19cb3babf370dc |
| institution | DOAJ |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2014-05-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-bc0d04fd5adb401f8c19cb3babf370dc2025-08-20T03:02:37ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-05-0105263510.21292/2075-1230-2014-0-5-26-3572FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGIONYa. R. Batyrshina0T. I. Petrenko1ФГБУ «Новосибирский научно-исследовательский институт туберкулеза» Минздрава РоссииФГБУ «Новосибирский научно-исследовательский институт туберкулеза» Минздрава РоссииA retrospective cohort study was performed to reveal risk factors for fluoroquinolone resistance in M. tuberculosis during treatment of 463 patients with multidrug-resistant (MDR) tuberculosis (TB) in the Novosibirsk Region. The factors associated with an increased risk were the extent of a TB process within > 2 lung segments (OR 1.39; 95% CI, 0.87-2.21), abundant bacterial excretion (OR 2.32; 95% CI, 1.54-3.5), primary aminoglycoside/capreomycin resistance in M. tuberculosis (OR 3.35; 95% CI, 1.80-6.24), concomitant alcohol/drug dependence (OR 1.46; 95 CI, 0.76-2.80), renal dysfunction (OR 4.60; 95% CI, 1.28-16.51), deviations from the standard polychemotherapy of MDR TB (OR 3.17; 95% CI, 1.58-6.34), fluoroquinolones used in doses lower than the recommended one (OR 5.23; 95% CI, 2.27-12.10), discontinuation of a polychemotherapy cycle (OR 5.70; 95% CI, 2.97-10.93), rural residence (OR 2.0; 95% CI: 1.14-3.51), and being in prison (OR 2.0; 95% CI, 1.14-3.51). Resection surgery (OR 0.48; 95% CI, 0.2-1.13), in-hospital intensive-phase polychemotherapy (OR 0.43; 95 CI, 0.27-0.63), and parenteral administration of anti-TB drugs (OR 0.40; 95% CI, 0.18-0.86) were associated with risk reduction.https://www.tibl-journal.com/jour/article/view/72m. tuberculosistuberculosis with multidrug resistance in the pathogenm. tuberculosisfluoroquinolone resistance |
| spellingShingle | Ya. R. Batyrshina T. I. Petrenko FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION Туберкулез и болезни лёгких m. tuberculosis tuberculosis with multidrug resistance in the pathogen m. tuberculosis fluoroquinolone resistance |
| title | FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION |
| title_full | FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION |
| title_fullStr | FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION |
| title_full_unstemmed | FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION |
| title_short | FACTORS ASSOCIATED WITH ACQUIRED FLUOROQUINOLONE RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS IN THE NOVOSIBIRSK REGION |
| title_sort | factors associated with acquired fluoroquinolone resistance in mycobacterium tuberculosis in the novosibirsk region |
| topic | m. tuberculosis tuberculosis with multidrug resistance in the pathogen m. tuberculosis fluoroquinolone resistance |
| url | https://www.tibl-journal.com/jour/article/view/72 |
| work_keys_str_mv | AT yarbatyrshina factorsassociatedwithacquiredfluoroquinoloneresistanceinmycobacteriumtuberculosisinthenovosibirskregion AT tipetrenko factorsassociatedwithacquiredfluoroquinoloneresistanceinmycobacteriumtuberculosisinthenovosibirskregion |