Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study
Background. Children affected by neurodevelopmental disability could experience early pubertal changes at least 20 times more than the general population. Limited data about central precocious puberty (CPP) among children affected by cerebral palsy (CP) are available. Methods. This is a longitudinal...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/4807163 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551140319821824 |
|---|---|
| author | Patrizia Bruzzi Maria Francesca Messina Alessandra Bartoli Barbara Predieri Laura Lucaccioni Simona Filomena Madeo Alberto Verrotti Filippo De Luca Lorenzo Iughetti |
| author_facet | Patrizia Bruzzi Maria Francesca Messina Alessandra Bartoli Barbara Predieri Laura Lucaccioni Simona Filomena Madeo Alberto Verrotti Filippo De Luca Lorenzo Iughetti |
| author_sort | Patrizia Bruzzi |
| collection | DOAJ |
| description | Background. Children affected by neurodevelopmental disability could experience early pubertal changes at least 20 times more than the general population. Limited data about central precocious puberty (CPP) among children affected by cerebral palsy (CP) are available. Methods. This is a longitudinal, observational, retrospective, case-control study involving 22 children affected by CPP and CP (group A), 22 paired with CP but without CPP (group B), and 22 children with CPP without CP. Auxological, biochemical, and instrumental data were collected at diagnosis of CPP and at 2 follow-up visits. Results. No differences were detected between groups A (at baseline) and B. At diagnosis of CPP, height SDS adjusted for target height (H-TH SDS) was significantly reduced in A than in C (−0.63 ± 1.94 versus 1.56 ± 1.38), while basal LH and oestradiol levels were significantly elevated in A than in C. During follow-up, despite an effective treatment, growth impairment deteriorated in A than in C (Δ H-SDS from diagnosis of CPP to last follow-up: −0.49 ± 0.91 versus 0.21 ± 0.33, p=0.023). Conclusions. Diagnosis of CPP could be partially mislead in CP due to growth failure that got worse during follow-up despite therapy. CPP in CP seems to progress rapidly along time supporting the hypothesis of a more intense activation of hypothalamic-pituitary-gonadal-axis in these patients. |
| format | Article |
| id | doaj-art-bc05d95f4f8e40b199e43be12b37abc0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-bc05d95f4f8e40b199e43be12b37abc02025-02-03T06:04:58ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/48071634807163Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian StudyPatrizia Bruzzi0Maria Francesca Messina1Alessandra Bartoli2Barbara Predieri3Laura Lucaccioni4Simona Filomena Madeo5Alberto Verrotti6Filippo De Luca7Lorenzo Iughetti8Department of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, University of Modena & Reggio Emilia, Via del Pozzo, No. 71, 41124 Modena, ItalyDepartment of Paediatrics, University of Messina, Padiglione NI Policlinico Universitario, Via Consolare Valeria, 98125 Messina, ItalyDepartment of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, University of Modena & Reggio Emilia, Via del Pozzo, No. 71, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, University of Modena & Reggio Emilia, Via del Pozzo, No. 71, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, University of Modena & Reggio Emilia, Via del Pozzo, No. 71, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, University of Modena & Reggio Emilia, Via del Pozzo, No. 71, 41124 Modena, ItalyDepartment of Pediatrics, University of Aquila, Via Vetoio (Coppito 2), 67100 Coppito, ItalyDepartment of Paediatrics, University of Messina, Padiglione NI Policlinico Universitario, Via Consolare Valeria, 98125 Messina, ItalyDepartment of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, University of Modena & Reggio Emilia, Via del Pozzo, No. 71, 41124 Modena, ItalyBackground. Children affected by neurodevelopmental disability could experience early pubertal changes at least 20 times more than the general population. Limited data about central precocious puberty (CPP) among children affected by cerebral palsy (CP) are available. Methods. This is a longitudinal, observational, retrospective, case-control study involving 22 children affected by CPP and CP (group A), 22 paired with CP but without CPP (group B), and 22 children with CPP without CP. Auxological, biochemical, and instrumental data were collected at diagnosis of CPP and at 2 follow-up visits. Results. No differences were detected between groups A (at baseline) and B. At diagnosis of CPP, height SDS adjusted for target height (H-TH SDS) was significantly reduced in A than in C (−0.63 ± 1.94 versus 1.56 ± 1.38), while basal LH and oestradiol levels were significantly elevated in A than in C. During follow-up, despite an effective treatment, growth impairment deteriorated in A than in C (Δ H-SDS from diagnosis of CPP to last follow-up: −0.49 ± 0.91 versus 0.21 ± 0.33, p=0.023). Conclusions. Diagnosis of CPP could be partially mislead in CP due to growth failure that got worse during follow-up despite therapy. CPP in CP seems to progress rapidly along time supporting the hypothesis of a more intense activation of hypothalamic-pituitary-gonadal-axis in these patients.http://dx.doi.org/10.1155/2017/4807163 |
| spellingShingle | Patrizia Bruzzi Maria Francesca Messina Alessandra Bartoli Barbara Predieri Laura Lucaccioni Simona Filomena Madeo Alberto Verrotti Filippo De Luca Lorenzo Iughetti Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study International Journal of Endocrinology |
| title | Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study |
| title_full | Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study |
| title_fullStr | Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study |
| title_full_unstemmed | Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study |
| title_short | Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study |
| title_sort | central precocious puberty and response to gnrha therapy in children with cerebral palsy and moderate to severe motor impairment data from a longitudinal case control multicentre italian study |
| url | http://dx.doi.org/10.1155/2017/4807163 |
| work_keys_str_mv | AT patriziabruzzi centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT mariafrancescamessina centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT alessandrabartoli centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT barbarapredieri centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT lauralucaccioni centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT simonafilomenamadeo centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT albertoverrotti centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT filippodeluca centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy AT lorenzoiughetti centralprecociouspubertyandresponsetognrhatherapyinchildrenwithcerebralpalsyandmoderatetoseveremotorimpairmentdatafromalongitudinalcasecontrolmulticentreitalianstudy |