Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate
The nuclear envelope (NE) is a dynamic, mechanosensitive structure that functions as a protective barrier for the genome and serves as a checkpoint responding to external stimuli. It plays a critical role in maintaining genomic stability and regulating cell fate. This review synthesizes recent resea...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Mechanobiology in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949907025000233 |
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| author | Chenyang Ji Junwei Chen Fuxiang Wei |
| author_facet | Chenyang Ji Junwei Chen Fuxiang Wei |
| author_sort | Chenyang Ji |
| collection | DOAJ |
| description | The nuclear envelope (NE) is a dynamic, mechanosensitive structure that functions as a protective barrier for the genome and serves as a checkpoint responding to external stimuli. It plays a critical role in maintaining genomic stability and regulating cell fate. This review synthesizes recent research highlighting the role of NE as a mechanical checkpoint in ensuring accurate chromosome segregation, regulating cell cycle progression, and contributing to cancer development. Chromosome mis-segregation during cell division is a major driver of aneuploidy, a condition closely associated with genomic instability and cellular transformation. The role of NE in chromatin organization and gene expression regulation is also discussed, underscoring its importance in cell differentiation and identity. |
| format | Article |
| id | doaj-art-bc04da022651498d9fe5e7e95d51929f |
| institution | DOAJ |
| issn | 2949-9070 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mechanobiology in Medicine |
| spelling | doaj-art-bc04da022651498d9fe5e7e95d51929f2025-08-20T03:22:09ZengElsevierMechanobiology in Medicine2949-90702025-06-013210013510.1016/j.mbm.2025.100135Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fateChenyang Ji0Junwei Chen1Fuxiang Wei2Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, ChinaCorresponding author.; Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, ChinaCorresponding author.; Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, ChinaThe nuclear envelope (NE) is a dynamic, mechanosensitive structure that functions as a protective barrier for the genome and serves as a checkpoint responding to external stimuli. It plays a critical role in maintaining genomic stability and regulating cell fate. This review synthesizes recent research highlighting the role of NE as a mechanical checkpoint in ensuring accurate chromosome segregation, regulating cell cycle progression, and contributing to cancer development. Chromosome mis-segregation during cell division is a major driver of aneuploidy, a condition closely associated with genomic instability and cellular transformation. The role of NE in chromatin organization and gene expression regulation is also discussed, underscoring its importance in cell differentiation and identity.http://www.sciencedirect.com/science/article/pii/S2949907025000233Nuclear envelopeMechanosensitive checkpointChromatinGene expressionCell cycle |
| spellingShingle | Chenyang Ji Junwei Chen Fuxiang Wei Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate Mechanobiology in Medicine Nuclear envelope Mechanosensitive checkpoint Chromatin Gene expression Cell cycle |
| title | Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate |
| title_full | Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate |
| title_fullStr | Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate |
| title_full_unstemmed | Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate |
| title_short | Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate |
| title_sort | mechanosensitive nuclear checkpoint nuclear envelope as a sensor of chromosomal instability and driver of cell fate |
| topic | Nuclear envelope Mechanosensitive checkpoint Chromatin Gene expression Cell cycle |
| url | http://www.sciencedirect.com/science/article/pii/S2949907025000233 |
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