The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study
Background: Three-dimensional echocardiography (3DE) allows simultaneous evaluation of the entire left ventricular (LV) volume, motion, and mechanical dyssynchrony. This study aimed to provide valuable data on the feasibility and reliability of 3DE in assessing LV dyssynchrony in healthy individual...
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Tehran University of Medical Sciences
2025-07-01
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| Series: | Frontiers in Biomedical Technologies |
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| Online Access: | https://fbt.tums.ac.ir/index.php/fbt/article/view/942 |
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| author | Parvaneh Aliakbarzadeh Naser Khezerlouy Aghdam Mehrnoosh Toufan |
| author_facet | Parvaneh Aliakbarzadeh Naser Khezerlouy Aghdam Mehrnoosh Toufan |
| author_sort | Parvaneh Aliakbarzadeh |
| collection | DOAJ |
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Background: Three-dimensional echocardiography (3DE) allows simultaneous evaluation of the entire left ventricular (LV) volume, motion, and mechanical dyssynchrony. This study aimed to provide valuable data on the feasibility and reliability of 3DE in assessing LV dyssynchrony in healthy individuals.
Methods: One hundred healthy volunteers, including both genders, with mean age, weight, and BMI of 39.64±10.21 years, 76.57±14.65 kg, and 27.59±4.3 kg.m-2, respectively, without evidence of structural heart or chronic disease, were included. 3DE examinations were conducted using a 4-chamber view and the full-volume method for all volunteers. Dyssynchrony was automatically quantified as the systolic dyssynchrony index (SDI) for selected LV segments using Q-lab software. The standard deviation (SD) of the time to attain minimum systolic volume was considered as SDI. This time length was expressed as % R-R to compensate for the variability of heart rate and increase reproducibility. Consequently, a single SDI (global SDI) was available for quantifying the degree of LV dyssynchrony by comparing all segments.
Results: According to echocardiographic findings, the mean global LV-SDI, apical SDI, basal SDI, and mid SDI were 28.68±15.48 msec, 26.16±27.47 msec, 24.41±14.35 msec, and 22.07±18.24 msec, respectively. After correction for RR duration, the mean global LV-SDI was 3.49±1.97%, apical SDI: 3.21±3.58%, basal SDI: 2.97±1.82%, and mid SDI: 2.68±2.19%.
Conclusion: 3DE proves to be a useful tool for evaluating LV dyssynchrony. The data provided include age- and sex-related changes in total and regional SDI in healthy volunteers, serving as a suitable reference for further investigations into LV dyssynchrony changes.
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| format | Article |
| id | doaj-art-bc04215128604653a4c6927d61dfc7a6 |
| institution | Kabale University |
| issn | 2345-5837 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Biomedical Technologies |
| spelling | doaj-art-bc04215128604653a4c6927d61dfc7a62025-08-20T03:40:33ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372025-07-0112310.18502/fbt.v12i3.19187The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot StudyParvaneh Aliakbarzadeh0Naser Khezerlouy Aghdam1Mehrnoosh Toufan2Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Background: Three-dimensional echocardiography (3DE) allows simultaneous evaluation of the entire left ventricular (LV) volume, motion, and mechanical dyssynchrony. This study aimed to provide valuable data on the feasibility and reliability of 3DE in assessing LV dyssynchrony in healthy individuals. Methods: One hundred healthy volunteers, including both genders, with mean age, weight, and BMI of 39.64±10.21 years, 76.57±14.65 kg, and 27.59±4.3 kg.m-2, respectively, without evidence of structural heart or chronic disease, were included. 3DE examinations were conducted using a 4-chamber view and the full-volume method for all volunteers. Dyssynchrony was automatically quantified as the systolic dyssynchrony index (SDI) for selected LV segments using Q-lab software. The standard deviation (SD) of the time to attain minimum systolic volume was considered as SDI. This time length was expressed as % R-R to compensate for the variability of heart rate and increase reproducibility. Consequently, a single SDI (global SDI) was available for quantifying the degree of LV dyssynchrony by comparing all segments. Results: According to echocardiographic findings, the mean global LV-SDI, apical SDI, basal SDI, and mid SDI were 28.68±15.48 msec, 26.16±27.47 msec, 24.41±14.35 msec, and 22.07±18.24 msec, respectively. After correction for RR duration, the mean global LV-SDI was 3.49±1.97%, apical SDI: 3.21±3.58%, basal SDI: 2.97±1.82%, and mid SDI: 2.68±2.19%. Conclusion: 3DE proves to be a useful tool for evaluating LV dyssynchrony. The data provided include age- and sex-related changes in total and regional SDI in healthy volunteers, serving as a suitable reference for further investigations into LV dyssynchrony changes. https://fbt.tums.ac.ir/index.php/fbt/article/view/942EchocardiographyThree-DimensionalVentricleHeart Failure |
| spellingShingle | Parvaneh Aliakbarzadeh Naser Khezerlouy Aghdam Mehrnoosh Toufan The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study Frontiers in Biomedical Technologies Echocardiography Three-Dimensional Ventricle Heart Failure |
| title | The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study |
| title_full | The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study |
| title_fullStr | The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study |
| title_full_unstemmed | The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study |
| title_short | The Feasibility of 3D Echocardiography Examination for Determining the Left Ventricular Dyssynchrony Index: A Pilot Study |
| title_sort | feasibility of 3d echocardiography examination for determining the left ventricular dyssynchrony index a pilot study |
| topic | Echocardiography Three-Dimensional Ventricle Heart Failure |
| url | https://fbt.tums.ac.ir/index.php/fbt/article/view/942 |
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