The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation
Conclusion: ITSA-1 enhances the recovery and survival of post-ROSC rats by diminishing histone acetylation and mitigating systemic inflammation. This effect is possibly due to the inhibition of glial cell activation, increased neuronal survival in the brain, and improved cardiac output (CO) and ejec...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/8156593 |
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| author | Chenyu Zhang Hongyan Wei Qiang Zhang Haohong Zhan Yuanzheng Lu Yujie Li Bo Li Wen Huang Feng Nian Rong Liu Chunlin Hu Jie Chen |
| author_facet | Chenyu Zhang Hongyan Wei Qiang Zhang Haohong Zhan Yuanzheng Lu Yujie Li Bo Li Wen Huang Feng Nian Rong Liu Chunlin Hu Jie Chen |
| author_sort | Chenyu Zhang |
| collection | DOAJ |
| description | Conclusion: ITSA-1 enhances the recovery and survival of post-ROSC rats by diminishing histone acetylation and mitigating systemic inflammation. This effect is possibly due to the inhibition of glial cell activation, increased neuronal survival in the brain, and improved cardiac output (CO) and ejection fraction (EF). |
| format | Article |
| id | doaj-art-bc02dc66dd00455ebb0f35da826ae42e |
| institution | OA Journals |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bc02dc66dd00455ebb0f35da826ae42e2025-08-20T02:10:30ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/8156593The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary ResuscitationChenyu Zhang0Hongyan Wei1Qiang Zhang2Haohong Zhan3Yuanzheng Lu4Yujie Li5Bo Li6Wen Huang7Feng Nian8Rong Liu9Chunlin Hu10Jie Chen11Department of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineDepartment of Emergency MedicineThe First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Emergency MedicineDepartment of Critical Care MedicineConclusion: ITSA-1 enhances the recovery and survival of post-ROSC rats by diminishing histone acetylation and mitigating systemic inflammation. This effect is possibly due to the inhibition of glial cell activation, increased neuronal survival in the brain, and improved cardiac output (CO) and ejection fraction (EF).http://dx.doi.org/10.1155/mi/8156593 |
| spellingShingle | Chenyu Zhang Hongyan Wei Qiang Zhang Haohong Zhan Yuanzheng Lu Yujie Li Bo Li Wen Huang Feng Nian Rong Liu Chunlin Hu Jie Chen The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation Mediators of Inflammation |
| title | The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation |
| title_full | The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation |
| title_fullStr | The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation |
| title_full_unstemmed | The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation |
| title_short | The Histone Deacetylase Activator ITSA-1 Improves the Prognosis of Cardiac Arrest Rats by Alleviating Systemic Inflammatory Responses Following Cardiopulmonary Resuscitation |
| title_sort | histone deacetylase activator itsa 1 improves the prognosis of cardiac arrest rats by alleviating systemic inflammatory responses following cardiopulmonary resuscitation |
| url | http://dx.doi.org/10.1155/mi/8156593 |
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