Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients
The role of nonclassical HLA-class Ib molecules HLA-G and HLA-E in the progression of Neuroblastoma (NB), the most common pediatric extracranial solid tumor, has been characterized in the last years. Since BM infiltration by NB cells is an adverse prognostic factor, we have here analyzed for the fir...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7465741 |
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| author | Fabio Morandi Sarah Pozzi Barbara Carlini Loredana Amoroso Vito Pistoia Maria Valeria Corrias |
| author_facet | Fabio Morandi Sarah Pozzi Barbara Carlini Loredana Amoroso Vito Pistoia Maria Valeria Corrias |
| author_sort | Fabio Morandi |
| collection | DOAJ |
| description | The role of nonclassical HLA-class Ib molecules HLA-G and HLA-E in the progression of Neuroblastoma (NB), the most common pediatric extracranial solid tumor, has been characterized in the last years. Since BM infiltration by NB cells is an adverse prognostic factor, we have here analyzed for the first time the concentration of soluble (s)HLA-G and HLA-E in bone marrow (BM) plasma samples from NB patients at diagnosis and healthy donors. sHLA-G and sHLA-E are present in BM plasma samples, and their levels were similar between NB patients and controls, thus suggesting that these molecules are physiologically released by resident or stromal BM cell populations. This hypothesis was supported by the finding that sHLA-G and sHLA-E levels did not correlate with BM infiltration and other adverse prognostic factors (MYCN amplification and age at diagnosis). In contrast, BM plasma levels of both molecules were higher in patients with metastatic disease than in patients with localized NB, thus suggesting that concentration of these molecules might be correlated with disease progression. The prognostic role of sHLA-G and sHLA-E concentration in the BM plasma for NB patients will be evaluated in future studies, by analyzing the clinical outcome of the same NB patients at follow-up. |
| format | Article |
| id | doaj-art-bc0290a1f64942eda48dc030f2694ee6 |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-bc0290a1f64942eda48dc030f2694ee62025-08-20T03:22:53ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/74657417465741Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma PatientsFabio Morandi0Sarah Pozzi1Barbara Carlini2Loredana Amoroso3Vito Pistoia4Maria Valeria Corrias5Laboratorio di Oncologia, Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genoa, ItalyCentro Cellule Staminali, IRCCS AOU San Martino-IST, Largo R. Benzi 10, 16132 Genoa, ItalyLaboratorio di Oncologia, Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genoa, ItalyUOC Oncologia, Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genoa, ItalyLaboratorio di Oncologia, Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genoa, ItalyLaboratorio di Oncologia, Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genoa, ItalyThe role of nonclassical HLA-class Ib molecules HLA-G and HLA-E in the progression of Neuroblastoma (NB), the most common pediatric extracranial solid tumor, has been characterized in the last years. Since BM infiltration by NB cells is an adverse prognostic factor, we have here analyzed for the first time the concentration of soluble (s)HLA-G and HLA-E in bone marrow (BM) plasma samples from NB patients at diagnosis and healthy donors. sHLA-G and sHLA-E are present in BM plasma samples, and their levels were similar between NB patients and controls, thus suggesting that these molecules are physiologically released by resident or stromal BM cell populations. This hypothesis was supported by the finding that sHLA-G and sHLA-E levels did not correlate with BM infiltration and other adverse prognostic factors (MYCN amplification and age at diagnosis). In contrast, BM plasma levels of both molecules were higher in patients with metastatic disease than in patients with localized NB, thus suggesting that concentration of these molecules might be correlated with disease progression. The prognostic role of sHLA-G and sHLA-E concentration in the BM plasma for NB patients will be evaluated in future studies, by analyzing the clinical outcome of the same NB patients at follow-up.http://dx.doi.org/10.1155/2016/7465741 |
| spellingShingle | Fabio Morandi Sarah Pozzi Barbara Carlini Loredana Amoroso Vito Pistoia Maria Valeria Corrias Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients Journal of Immunology Research |
| title | Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients |
| title_full | Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients |
| title_fullStr | Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients |
| title_full_unstemmed | Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients |
| title_short | Soluble HLA-G and HLA-E Levels in Bone Marrow Plasma Samples Are Related to Disease Stage in Neuroblastoma Patients |
| title_sort | soluble hla g and hla e levels in bone marrow plasma samples are related to disease stage in neuroblastoma patients |
| url | http://dx.doi.org/10.1155/2016/7465741 |
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