Nonsegmental Vitiligo and Autoimmune Mechanism

Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, par...

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Main Authors: Naoki Oiso, Tamio Suzuki, Kazuyoshi Fukai, Ichiro Katayama, Akira Kawada
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Dermatology Research and Practice
Online Access:http://dx.doi.org/10.1155/2011/518090
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author Naoki Oiso
Tamio Suzuki
Kazuyoshi Fukai
Ichiro Katayama
Akira Kawada
author_facet Naoki Oiso
Tamio Suzuki
Kazuyoshi Fukai
Ichiro Katayama
Akira Kawada
author_sort Naoki Oiso
collection DOAJ
description Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo.
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spelling doaj-art-bbfa1da506a842f3989cab03094c71ae2025-08-20T02:18:43ZengWileyDermatology Research and Practice1687-61051687-61132011-01-01201110.1155/2011/518090518090Nonsegmental Vitiligo and Autoimmune MechanismNaoki Oiso0Tamio Suzuki1Kazuyoshi Fukai2Ichiro Katayama3Akira Kawada4Department of Dermatology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Dermatology, Yamagata University School of Medicine, Yamagata 990-9585, JapanDepartment of Dermatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, JapanDepartment of Dermatology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Dermatology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, JapanNonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It is frequently associated with other autoimmune diseases, particularly autoimmune thyroid diseases including Hashimoto's thyroiditis and Graves' disease, rheumatoid arthritis, type 1 diabetes, psoriasis, pernicious anemia, systemic lupus erythematosus, Addison's disease, and alopecia areata. This indicates the presence of genetically determined susceptibility to not only vitiligo but also to other autoimmune disorders. Here, we summarize current understanding of autoimmune pathogenesis in non-segmental vitiligo.http://dx.doi.org/10.1155/2011/518090
spellingShingle Naoki Oiso
Tamio Suzuki
Kazuyoshi Fukai
Ichiro Katayama
Akira Kawada
Nonsegmental Vitiligo and Autoimmune Mechanism
Dermatology Research and Practice
title Nonsegmental Vitiligo and Autoimmune Mechanism
title_full Nonsegmental Vitiligo and Autoimmune Mechanism
title_fullStr Nonsegmental Vitiligo and Autoimmune Mechanism
title_full_unstemmed Nonsegmental Vitiligo and Autoimmune Mechanism
title_short Nonsegmental Vitiligo and Autoimmune Mechanism
title_sort nonsegmental vitiligo and autoimmune mechanism
url http://dx.doi.org/10.1155/2011/518090
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AT ichirokatayama nonsegmentalvitiligoandautoimmunemechanism
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