Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/731023 |
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| _version_ | 1850178432313327616 |
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| author | Roman Günthner Hans-Joachim Anders |
| author_facet | Roman Günthner Hans-Joachim Anders |
| author_sort | Roman Günthner |
| collection | DOAJ |
| description | The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization. |
| format | Article |
| id | doaj-art-bbf8d652283645e6afb653f3a1214408 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bbf8d652283645e6afb653f3a12144082025-08-20T02:18:43ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/731023731023Interferon-Regulatory Factors Determine Macrophage Phenotype PolarizationRoman Günthner0Hans-Joachim Anders1Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, 80336 München, GermanyNephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, 80336 München, GermanyThe mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.http://dx.doi.org/10.1155/2013/731023 |
| spellingShingle | Roman Günthner Hans-Joachim Anders Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization Mediators of Inflammation |
| title | Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization |
| title_full | Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization |
| title_fullStr | Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization |
| title_full_unstemmed | Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization |
| title_short | Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization |
| title_sort | interferon regulatory factors determine macrophage phenotype polarization |
| url | http://dx.doi.org/10.1155/2013/731023 |
| work_keys_str_mv | AT romangunthner interferonregulatoryfactorsdeterminemacrophagephenotypepolarization AT hansjoachimanders interferonregulatoryfactorsdeterminemacrophagephenotypepolarization |