Photodynamic therapy in the combined treatment of choroidal melanoma
Purpose. To evaluate the effectiveness of the combined treatment of choroidal melanoma (CM) based on the use of PDT and Ru-106+Rh-106 brachytherapy (BT). Material and methods. Retrospective analysis was carried out in 48 patients (48 eyes) with CM. Distribution of patients according to TNM system: T...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Publishing house "Ophthalmology"
2024-06-01
|
| Series: | Офтальмохирургия |
| Subjects: | |
| Online Access: | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/636/911 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850272634716028928 |
|---|---|
| author | E.V. Samkovich I.E. Panova E.V. Boyko E.M. Svistunova A.A. Bykhovskii |
| author_facet | E.V. Samkovich I.E. Panova E.V. Boyko E.M. Svistunova A.A. Bykhovskii |
| author_sort | E.V. Samkovich |
| collection | DOAJ |
| description | Purpose. To evaluate the effectiveness of the combined treatment of choroidal melanoma (CM) based on the use of PDT and Ru-106+Rh-106 brachytherapy (BT). Material and methods. Retrospective analysis was carried out in 48 patients (48 eyes) with CM. Distribution of patients according to TNM system: T1N0M0 – 2 patients, T2N0M0 – 14, T3N0M0 – 32. All patients were divided into 2 study groups: 1st group – 25 patients (25 eyes) who underwent Ru/Ro-106 BT in isolation, SOD 125.4±12.3 Gy; 2nd group – 23 patients (23 eyes) who underwent combined treatment: Ru-106+Rh-106 BT (SOD 127.3±13.6 Gy) + PDT. Diagnostics was carried out on the basis of clinical and instrumental examination including complex ultrasound with estimation of the tumor vascularization degree. Results. Application of complex organ preservation treatment, including photodynamic therapy, followed by BT promotes acceleration of rates of tumor regression in 3, 6, 12 months (p<0.05). It was reliably found that the signs of intratumoral vascularization of CM (p<0.05) decrease after a combined treatment. Acomparative analysis of the effectiveness of the two variants of organ preservation treatment of CM has shown a higher efficacy of PDT and BT, based on complete regression of the tumor and local control in a significantly larger number of patients (p<0.05). Conclusion. The results of application of PDT in the combined treatment of CM show the prospects of the method application to achieve a faster rate of tumor regression and a preventive measure of haematogenous metastasis due to necrosis and blocking of vessels feeding the tumor. |
| format | Article |
| id | doaj-art-bbf5506987a34d9e910ebb7ea3adcb07 |
| institution | OA Journals |
| issn | 0235-4160 2312-4970 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | Publishing house "Ophthalmology" |
| record_format | Article |
| series | Офтальмохирургия |
| spelling | doaj-art-bbf5506987a34d9e910ebb7ea3adcb072025-08-20T01:51:44ZrusPublishing house "Ophthalmology"Офтальмохирургия0235-41602312-49702024-06-0113929910810.25276/0235-4160-2024-2-99-108Photodynamic therapy in the combined treatment of choroidal melanomaE.V. Samkovich0https://orcid.org/0000-0002-5573-5712I.E. Panova1https://orcid.org/0000-0001-7443-4555E.V. Boyko2https://orcid.org/0000-0002-7413-7478E.M. Svistunova3https://orcid.org/0009-0000-2126-4345A.A. Bykhovskii4https://orcid.org/0000-0003-1559-2793S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. PetersburgS. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. PetersburgS. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. Petersburg; North-Western State Medical University named after I.I. Mechnikov, St. PetersburgS. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. PetersburgS. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg Branch, St. PetersburgPurpose. To evaluate the effectiveness of the combined treatment of choroidal melanoma (CM) based on the use of PDT and Ru-106+Rh-106 brachytherapy (BT). Material and methods. Retrospective analysis was carried out in 48 patients (48 eyes) with CM. Distribution of patients according to TNM system: T1N0M0 – 2 patients, T2N0M0 – 14, T3N0M0 – 32. All patients were divided into 2 study groups: 1st group – 25 patients (25 eyes) who underwent Ru/Ro-106 BT in isolation, SOD 125.4±12.3 Gy; 2nd group – 23 patients (23 eyes) who underwent combined treatment: Ru-106+Rh-106 BT (SOD 127.3±13.6 Gy) + PDT. Diagnostics was carried out on the basis of clinical and instrumental examination including complex ultrasound with estimation of the tumor vascularization degree. Results. Application of complex organ preservation treatment, including photodynamic therapy, followed by BT promotes acceleration of rates of tumor regression in 3, 6, 12 months (p<0.05). It was reliably found that the signs of intratumoral vascularization of CM (p<0.05) decrease after a combined treatment. Acomparative analysis of the effectiveness of the two variants of organ preservation treatment of CM has shown a higher efficacy of PDT and BT, based on complete regression of the tumor and local control in a significantly larger number of patients (p<0.05). Conclusion. The results of application of PDT in the combined treatment of CM show the prospects of the method application to achieve a faster rate of tumor regression and a preventive measure of haematogenous metastasis due to necrosis and blocking of vessels feeding the tumor.https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/636/911choroidal melanomaphotodynamic therapybrachytherapyuveal melanomaophthalmo-oncologychoroidal melanoma treatment |
| spellingShingle | E.V. Samkovich I.E. Panova E.V. Boyko E.M. Svistunova A.A. Bykhovskii Photodynamic therapy in the combined treatment of choroidal melanoma Офтальмохирургия choroidal melanoma photodynamic therapy brachytherapy uveal melanoma ophthalmo-oncology choroidal melanoma treatment |
| title | Photodynamic therapy in the combined treatment of choroidal melanoma |
| title_full | Photodynamic therapy in the combined treatment of choroidal melanoma |
| title_fullStr | Photodynamic therapy in the combined treatment of choroidal melanoma |
| title_full_unstemmed | Photodynamic therapy in the combined treatment of choroidal melanoma |
| title_short | Photodynamic therapy in the combined treatment of choroidal melanoma |
| title_sort | photodynamic therapy in the combined treatment of choroidal melanoma |
| topic | choroidal melanoma photodynamic therapy brachytherapy uveal melanoma ophthalmo-oncology choroidal melanoma treatment |
| url | https://ophthalmosurgery.ru/index.php/ophthalmosurgery/article/view/636/911 |
| work_keys_str_mv | AT evsamkovich photodynamictherapyinthecombinedtreatmentofchoroidalmelanoma AT iepanova photodynamictherapyinthecombinedtreatmentofchoroidalmelanoma AT evboyko photodynamictherapyinthecombinedtreatmentofchoroidalmelanoma AT emsvistunova photodynamictherapyinthecombinedtreatmentofchoroidalmelanoma AT aabykhovskii photodynamictherapyinthecombinedtreatmentofchoroidalmelanoma |