IR780-Based Nanotheranostics and In Vivo Effects: A Review
Photodynamic and photothermal therapies with IR780 have gained exponential interest, and their photophysical properties have demonstrated promise for use in antitumor and antimicrobial chemotherapy. IR780 and its derivatives are valuable in labeling nanostructures with different chemical composition...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Journal of Nanotheranostics |
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| Online Access: | https://www.mdpi.com/2624-845X/6/1/8 |
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| _version_ | 1850090349381287936 |
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| author | Márcia Célia Pacheco Fialho Maria Alice de Oliveira Marina Guimarães Carvalho Machado Carlos Marchiorio Lacerda Vanessa Carla Furtado Mosqueira |
| author_facet | Márcia Célia Pacheco Fialho Maria Alice de Oliveira Marina Guimarães Carvalho Machado Carlos Marchiorio Lacerda Vanessa Carla Furtado Mosqueira |
| author_sort | Márcia Célia Pacheco Fialho |
| collection | DOAJ |
| description | Photodynamic and photothermal therapies with IR780 have gained exponential interest, and their photophysical properties have demonstrated promise for use in antitumor and antimicrobial chemotherapy. IR780 and its derivatives are valuable in labeling nanostructures with different chemical compositions for in vitro and in vivo fluorescence monitoring studies in the near-infrared (NIR) spectrum. The current literature is abundant on this topic, particularly with applications in the treatment of different types of cancer using laser illumination to produce photodynamic (PDT), photothermal (PTT), and, more recently, sonodynamic therapy (SDT) approaches for cell death. This review aims to update the state of the art concerning IR780 photosensitizer as a theranostic agent for PDT, PTT, SDT, and photoacoustic (PA) effects, and fluorescence imaging monitoring associated with different types of nanocarriers. The literature update concerns a period from 2017 to 2024, considering, more specifically, the in vivo effects found in preclinical experiments. Some aspects of the labeling stability of nanostructured systems will be discussed based on the evidence of IR780 leakage from the nanocarrier and its consequences for the reliable analysis of biological data. |
| format | Article |
| id | doaj-art-bbf15fa9bb52485d8d8979e9031a5f71 |
| institution | DOAJ |
| issn | 2624-845X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Nanotheranostics |
| spelling | doaj-art-bbf15fa9bb52485d8d8979e9031a5f712025-08-20T02:42:35ZengMDPI AGJournal of Nanotheranostics2624-845X2025-03-0161810.3390/jnt6010008IR780-Based Nanotheranostics and In Vivo Effects: A ReviewMárcia Célia Pacheco Fialho0Maria Alice de Oliveira1Marina Guimarães Carvalho Machado2Carlos Marchiorio Lacerda3Vanessa Carla Furtado Mosqueira4Laboratory of Pharmaceutics and Nanotechnology, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto CEP 35400-000, Minas Gerais, BrazilLaboratory of Pharmaceutics and Nanotechnology, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto CEP 35400-000, Minas Gerais, BrazilLaboratory of Pharmaceutics and Nanotechnology, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto CEP 35400-000, Minas Gerais, BrazilLaboratory of Pharmaceutics and Nanotechnology, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto CEP 35400-000, Minas Gerais, BrazilLaboratory of Pharmaceutics and Nanotechnology, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto CEP 35400-000, Minas Gerais, BrazilPhotodynamic and photothermal therapies with IR780 have gained exponential interest, and their photophysical properties have demonstrated promise for use in antitumor and antimicrobial chemotherapy. IR780 and its derivatives are valuable in labeling nanostructures with different chemical compositions for in vitro and in vivo fluorescence monitoring studies in the near-infrared (NIR) spectrum. The current literature is abundant on this topic, particularly with applications in the treatment of different types of cancer using laser illumination to produce photodynamic (PDT), photothermal (PTT), and, more recently, sonodynamic therapy (SDT) approaches for cell death. This review aims to update the state of the art concerning IR780 photosensitizer as a theranostic agent for PDT, PTT, SDT, and photoacoustic (PA) effects, and fluorescence imaging monitoring associated with different types of nanocarriers. The literature update concerns a period from 2017 to 2024, considering, more specifically, the in vivo effects found in preclinical experiments. Some aspects of the labeling stability of nanostructured systems will be discussed based on the evidence of IR780 leakage from the nanocarrier and its consequences for the reliable analysis of biological data.https://www.mdpi.com/2624-845X/6/1/8heptamethine cyaninebiodistributionantitumoralphotodynamicphotothermalsonodynamic |
| spellingShingle | Márcia Célia Pacheco Fialho Maria Alice de Oliveira Marina Guimarães Carvalho Machado Carlos Marchiorio Lacerda Vanessa Carla Furtado Mosqueira IR780-Based Nanotheranostics and In Vivo Effects: A Review Journal of Nanotheranostics heptamethine cyanine biodistribution antitumoral photodynamic photothermal sonodynamic |
| title | IR780-Based Nanotheranostics and In Vivo Effects: A Review |
| title_full | IR780-Based Nanotheranostics and In Vivo Effects: A Review |
| title_fullStr | IR780-Based Nanotheranostics and In Vivo Effects: A Review |
| title_full_unstemmed | IR780-Based Nanotheranostics and In Vivo Effects: A Review |
| title_short | IR780-Based Nanotheranostics and In Vivo Effects: A Review |
| title_sort | ir780 based nanotheranostics and in vivo effects a review |
| topic | heptamethine cyanine biodistribution antitumoral photodynamic photothermal sonodynamic |
| url | https://www.mdpi.com/2624-845X/6/1/8 |
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