A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response
Abstract Objective The purpose of this study is to investigate the differential effects of left versus right stellate ganglion block (SGB) on perioperative stress response. Methods Sixty patients scheduled for elective laparoscopic cholecystectomy were randomly divided into two groups, the left SGB...
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BMC
2025-07-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-025-03272-y |
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| author | Wei Jiang Liu Yang Xia Zheng |
| author_facet | Wei Jiang Liu Yang Xia Zheng |
| author_sort | Wei Jiang |
| collection | DOAJ |
| description | Abstract Objective The purpose of this study is to investigate the differential effects of left versus right stellate ganglion block (SGB) on perioperative stress response. Methods Sixty patients scheduled for elective laparoscopic cholecystectomy were randomly divided into two groups, the left SGB (LSGB) group and the right SGB (RSGB) group. After routine general anesthesia, ultrasound-guided left or right SGB was performed 20 min before anesthesia induction in the LSGB and RSGB groups. The primary outcome was the difference in blood pressure and heart rate recorded at T1 (admission), T2 (before anesthesia induction), T3 (immediately after intubation), T4 (after pneumoperitoneum establishment), T5 (postoperative end), and T6 (exit). Serum cortisol levels measured at T1, T3, T4, and T6, and adverse reactions were regarded as secondary outcomes. Results The heart rate at T2 and T3 in the RSGB group was sharply lower than that in the LSGB group (P < 0.05). No significant differences were observed in heart rate and blood pressure in the two groups at the other time points (P > 0.05). No significant differences were observed in serum cortisol levels and adverse reactions between the two groups (P > 0.05). Conclusion Right SGB has a more significant short-term effect on heart rate reduction than left stellate ganglion block. Serum cortisol levels and adverse reactions were comparable between the two groups. Clinical trial The project was registered in the Chinese Clinical Trial Registry (ChiCTR2100053789) on 2021/11/29. |
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| id | doaj-art-bbf1128209e7446c8faee0bdf1c4a124 |
| institution | Kabale University |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-bbf1128209e7446c8faee0bdf1c4a1242025-08-20T03:46:19ZengBMCBMC Anesthesiology1471-22532025-07-012511810.1186/s12871-025-03272-yA prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress responseWei Jiang0Liu Yang1Xia Zheng2Deparment of Anesthesiology, Yongchuan Hospital of Chongqing Medical UniversityDeparment of Anesthesiology, Yongchuan Hospital of Chongqing Medical UniversityDeparment of Anesthesiology, Yongchuan Hospital of Chongqing Medical UniversityAbstract Objective The purpose of this study is to investigate the differential effects of left versus right stellate ganglion block (SGB) on perioperative stress response. Methods Sixty patients scheduled for elective laparoscopic cholecystectomy were randomly divided into two groups, the left SGB (LSGB) group and the right SGB (RSGB) group. After routine general anesthesia, ultrasound-guided left or right SGB was performed 20 min before anesthesia induction in the LSGB and RSGB groups. The primary outcome was the difference in blood pressure and heart rate recorded at T1 (admission), T2 (before anesthesia induction), T3 (immediately after intubation), T4 (after pneumoperitoneum establishment), T5 (postoperative end), and T6 (exit). Serum cortisol levels measured at T1, T3, T4, and T6, and adverse reactions were regarded as secondary outcomes. Results The heart rate at T2 and T3 in the RSGB group was sharply lower than that in the LSGB group (P < 0.05). No significant differences were observed in heart rate and blood pressure in the two groups at the other time points (P > 0.05). No significant differences were observed in serum cortisol levels and adverse reactions between the two groups (P > 0.05). Conclusion Right SGB has a more significant short-term effect on heart rate reduction than left stellate ganglion block. Serum cortisol levels and adverse reactions were comparable between the two groups. Clinical trial The project was registered in the Chinese Clinical Trial Registry (ChiCTR2100053789) on 2021/11/29.https://doi.org/10.1186/s12871-025-03272-yStellate ganglionNerve blockStress response |
| spellingShingle | Wei Jiang Liu Yang Xia Zheng A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response BMC Anesthesiology Stellate ganglion Nerve block Stress response |
| title | A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response |
| title_full | A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response |
| title_fullStr | A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response |
| title_full_unstemmed | A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response |
| title_short | A prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response |
| title_sort | prospective randomized clinical trial on the differential effect of left versus right stellate ganglion block on perioperative stress response |
| topic | Stellate ganglion Nerve block Stress response |
| url | https://doi.org/10.1186/s12871-025-03272-y |
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