Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells
Chemical investigation on the whole herb of <i>Peperomia heyneana</i> Miq. resulted in the isolation of six lignans, including two previously undescribed compounds, named peperomianan A and B (<b>1</b>–<b>2</b>), and four known compounds, 1,2-cyclobutanedicarboxyl...
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MDPI AG
2025-04-01
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| author | Yufei Xi Juan Liu Congcong Gao Mingxuan Zhu Baomin Feng Xuan Lu |
| author_facet | Yufei Xi Juan Liu Congcong Gao Mingxuan Zhu Baomin Feng Xuan Lu |
| author_sort | Yufei Xi |
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| description | Chemical investigation on the whole herb of <i>Peperomia heyneana</i> Miq. resulted in the isolation of six lignans, including two previously undescribed compounds, named peperomianan A and B (<b>1</b>–<b>2</b>), and four known compounds, 1,2-cyclobutanedicarboxylic acid (<b>3</b>), (+)-medioresinol (<b>4</b>), (+)-pinoresinol (<b>5</b>), and (+)-yangambin (<b>6</b>). Their structures were established by extensive spectroscopic analyses. The absolute configuration of compound <b>1</b> was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Subsequently, the effects of all isolates on BPH-1 cells were evaluated in vitro by MTT assay. |
| format | Article |
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| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
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| series | Molecules |
| spelling | doaj-art-bbef63e0042a4375a5ec2cb125cea5422025-08-20T02:28:41ZengMDPI AGMolecules1420-30492025-04-01308180910.3390/molecules30081809Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 CellsYufei Xi0Juan Liu1Congcong Gao2Mingxuan Zhu3Baomin Feng4Xuan Lu5College of Life and Health, Dalian University, Dalian 116622, ChinaCollege of Life and Health, Dalian University, Dalian 116622, ChinaCollege of Life and Health, Dalian University, Dalian 116622, ChinaCollege of Life and Health, Dalian University, Dalian 116622, ChinaCollege of Life and Health, Dalian University, Dalian 116622, ChinaCollege of Life and Health, Dalian University, Dalian 116622, ChinaChemical investigation on the whole herb of <i>Peperomia heyneana</i> Miq. resulted in the isolation of six lignans, including two previously undescribed compounds, named peperomianan A and B (<b>1</b>–<b>2</b>), and four known compounds, 1,2-cyclobutanedicarboxylic acid (<b>3</b>), (+)-medioresinol (<b>4</b>), (+)-pinoresinol (<b>5</b>), and (+)-yangambin (<b>6</b>). Their structures were established by extensive spectroscopic analyses. The absolute configuration of compound <b>1</b> was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Subsequently, the effects of all isolates on BPH-1 cells were evaluated in vitro by MTT assay.https://www.mdpi.com/1420-3049/30/8/1809<i>Peperomia heyneana</i>lignansBPHstructure elucidation |
| spellingShingle | Yufei Xi Juan Liu Congcong Gao Mingxuan Zhu Baomin Feng Xuan Lu Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells Molecules <i>Peperomia heyneana</i> lignans BPH structure elucidation |
| title | Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells |
| title_full | Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells |
| title_fullStr | Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells |
| title_full_unstemmed | Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells |
| title_short | Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells |
| title_sort | discovery of lignans from the herbs of i peperomia heyneana i with inhibitory activities on bph 1 cells |
| topic | <i>Peperomia heyneana</i> lignans BPH structure elucidation |
| url | https://www.mdpi.com/1420-3049/30/8/1809 |
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