Discovery of Lignans from the Herbs of <i>Peperomia heyneana</i> with Inhibitory Activities on BPH-1 Cells
Chemical investigation on the whole herb of <i>Peperomia heyneana</i> Miq. resulted in the isolation of six lignans, including two previously undescribed compounds, named peperomianan A and B (<b>1</b>–<b>2</b>), and four known compounds, 1,2-cyclobutanedicarboxyl...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/8/1809 |
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| Summary: | Chemical investigation on the whole herb of <i>Peperomia heyneana</i> Miq. resulted in the isolation of six lignans, including two previously undescribed compounds, named peperomianan A and B (<b>1</b>–<b>2</b>), and four known compounds, 1,2-cyclobutanedicarboxylic acid (<b>3</b>), (+)-medioresinol (<b>4</b>), (+)-pinoresinol (<b>5</b>), and (+)-yangambin (<b>6</b>). Their structures were established by extensive spectroscopic analyses. The absolute configuration of compound <b>1</b> was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Subsequently, the effects of all isolates on BPH-1 cells were evaluated in vitro by MTT assay. |
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| ISSN: | 1420-3049 |