Mesenchymal Stem Cells Derived from Dental Pulp: A Review
The mesenchymal stem cells of dental pulp (DPSCs) were isolated and characterized for the first time more than a decade ago as highly clonogenic cells that were able to generate densely calcified colonies. Now, DPSCs are considered to have potential as stem cell source for orthopedic and oral maxill...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/4709572 |
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| author | Edgar Ledesma-Martínez Víctor Manuel Mendoza-Núñez Edelmiro Santiago-Osorio |
| author_facet | Edgar Ledesma-Martínez Víctor Manuel Mendoza-Núñez Edelmiro Santiago-Osorio |
| author_sort | Edgar Ledesma-Martínez |
| collection | DOAJ |
| description | The mesenchymal stem cells of dental pulp (DPSCs) were isolated and characterized for the first time more than a decade ago as highly clonogenic cells that were able to generate densely calcified colonies. Now, DPSCs are considered to have potential as stem cell source for orthopedic and oral maxillofacial reconstruction, and it has been suggested that they may have applications beyond the scope of the stomatognathic system. To date, most studies have shown that, regardless of their origin in third molars, incisors, or exfoliated deciduous teeth, DPSCs can generate mineralized tissue, an extracellular matrix and structures type dentin, periodontal ligament, and dental pulp, as well as other structures. Different groups worldwide have designed and evaluated new efficient protocols for the isolation, expansion, and maintenance of clinically safe human DPSCs in sufficient numbers for various therapeutics protocols and have discussed the most appropriate route of administration, the possible contraindications to their clinical use, and the parameters to be considered for monitoring their clinical efficacy and proper biological source. At present, DPSC-based therapy is promising but because most of the available evidence was obtained using nonhuman xenotransplants, it is not a mature technology. |
| format | Article |
| id | doaj-art-bbee2579a9864f588b1c2021b976f3f1 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-bbee2579a9864f588b1c2021b976f3f12025-02-03T01:24:17ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/47095724709572Mesenchymal Stem Cells Derived from Dental Pulp: A ReviewEdgar Ledesma-Martínez0Víctor Manuel Mendoza-Núñez1Edelmiro Santiago-Osorio2Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, MEX, MexicoResearch Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, MEX, MexicoHematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, MEX, MexicoThe mesenchymal stem cells of dental pulp (DPSCs) were isolated and characterized for the first time more than a decade ago as highly clonogenic cells that were able to generate densely calcified colonies. Now, DPSCs are considered to have potential as stem cell source for orthopedic and oral maxillofacial reconstruction, and it has been suggested that they may have applications beyond the scope of the stomatognathic system. To date, most studies have shown that, regardless of their origin in third molars, incisors, or exfoliated deciduous teeth, DPSCs can generate mineralized tissue, an extracellular matrix and structures type dentin, periodontal ligament, and dental pulp, as well as other structures. Different groups worldwide have designed and evaluated new efficient protocols for the isolation, expansion, and maintenance of clinically safe human DPSCs in sufficient numbers for various therapeutics protocols and have discussed the most appropriate route of administration, the possible contraindications to their clinical use, and the parameters to be considered for monitoring their clinical efficacy and proper biological source. At present, DPSC-based therapy is promising but because most of the available evidence was obtained using nonhuman xenotransplants, it is not a mature technology.http://dx.doi.org/10.1155/2016/4709572 |
| spellingShingle | Edgar Ledesma-Martínez Víctor Manuel Mendoza-Núñez Edelmiro Santiago-Osorio Mesenchymal Stem Cells Derived from Dental Pulp: A Review Stem Cells International |
| title | Mesenchymal Stem Cells Derived from Dental Pulp: A Review |
| title_full | Mesenchymal Stem Cells Derived from Dental Pulp: A Review |
| title_fullStr | Mesenchymal Stem Cells Derived from Dental Pulp: A Review |
| title_full_unstemmed | Mesenchymal Stem Cells Derived from Dental Pulp: A Review |
| title_short | Mesenchymal Stem Cells Derived from Dental Pulp: A Review |
| title_sort | mesenchymal stem cells derived from dental pulp a review |
| url | http://dx.doi.org/10.1155/2016/4709572 |
| work_keys_str_mv | AT edgarledesmamartinez mesenchymalstemcellsderivedfromdentalpulpareview AT victormanuelmendozanunez mesenchymalstemcellsderivedfromdentalpulpareview AT edelmirosantiagoosorio mesenchymalstemcellsderivedfromdentalpulpareview |