CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity
Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging. This review summarized the development of CAR-T technolo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519671/full |
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| _version_ | 1841553918094475264 |
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| author | Yaojie Kong Jingyao Li Xueyao Zhao Yanwei Wu Liang Chen |
| author_facet | Yaojie Kong Jingyao Li Xueyao Zhao Yanwei Wu Liang Chen |
| author_sort | Yaojie Kong |
| collection | DOAJ |
| description | Chimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging. This review summarized the development of CAR-T technologies, emphasized the challenges and solutions in CAR-T cell therapy for solid tumors. Also, key innovations were discussed including specialized CAR-T, combination therapies and the novel use of CAR-Treg, CAR-NK and CAR-M cells. Besides, CAR-based cell therapy have extended its reach beyond oncology to autoimmune disorders. We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. By highlighting these cutting-edge developments, this review underscores the transformative potential of CAR technologies in clinical practice. |
| format | Article |
| id | doaj-art-bbec183249c64c84803ec2c17bb50515 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-bbec183249c64c84803ec2c17bb505152025-01-09T06:10:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15196711519671CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunityYaojie KongJingyao LiXueyao ZhaoYanwei WuLiang ChenChimeric Antigen Receptor (CAR)-T cell therapy has rapidly emerged as a groundbreaking approach in cancer treatment, particularly for hematologic malignancies. However, the application of CAR-T cell therapy in solid tumors remains challenging. This review summarized the development of CAR-T technologies, emphasized the challenges and solutions in CAR-T cell therapy for solid tumors. Also, key innovations were discussed including specialized CAR-T, combination therapies and the novel use of CAR-Treg, CAR-NK and CAR-M cells. Besides, CAR-based cell therapy have extended its reach beyond oncology to autoimmune disorders. We reviewed preclinical experiments and clinical trials involving CAR-T, Car-Treg and CAAR-T cell therapies in various autoimmune diseases. By highlighting these cutting-edge developments, this review underscores the transformative potential of CAR technologies in clinical practice.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519671/fullCAR-T cell therapysolid tumorsautoimmune diseasesdual-CAR strategyCAR-Treg |
| spellingShingle | Yaojie Kong Jingyao Li Xueyao Zhao Yanwei Wu Liang Chen CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity Frontiers in Immunology CAR-T cell therapy solid tumors autoimmune diseases dual-CAR strategy CAR-Treg |
| title | CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity |
| title_full | CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity |
| title_fullStr | CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity |
| title_full_unstemmed | CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity |
| title_short | CAR-T cell therapy: developments, challenges and expanded applications from cancer to autoimmunity |
| title_sort | car t cell therapy developments challenges and expanded applications from cancer to autoimmunity |
| topic | CAR-T cell therapy solid tumors autoimmune diseases dual-CAR strategy CAR-Treg |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519671/full |
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