Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry
Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodo...
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2025-08-01
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| Online Access: | https://doi.org/10.1186/s13104-025-07443-5 |
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| author | Eirini Chatzopoulou Galinos Fanourakis Nikolaos Papanikolaou Ioulia Chatzistamou Xanthippi Dereka Heleni Vastardis |
| author_facet | Eirini Chatzopoulou Galinos Fanourakis Nikolaos Papanikolaou Ioulia Chatzistamou Xanthippi Dereka Heleni Vastardis |
| author_sort | Eirini Chatzopoulou |
| collection | DOAJ |
| description | Abstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility. |
| format | Article |
| id | doaj-art-bbe6c9789f5c4d8e858ffe5e8cb97dc1 |
| institution | Kabale University |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-bbe6c9789f5c4d8e858ffe5e8cb97dc12025-08-24T11:06:08ZengBMCBMC Research Notes1756-05002025-08-011811510.1186/s13104-025-07443-5Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestryEirini Chatzopoulou0Galinos Fanourakis1Nikolaos Papanikolaou2Ioulia Chatzistamou3Xanthippi Dereka4Heleni Vastardis5U.F.R. d’Odontologie, Université Paris CitéDepartment of Oral Biology, School of Dentistry, National and Kapodistrian University of AthensEnzyQuest PC, Science and Technology Park of CreteDepartment of Pathology, Microbiology and Immunology, School of Medicine, University of South CarolinaDepartment of Periodontology, School of Dentistry, National and Kapodistrian University of AthensDepartment of Orthodontics, School of Dentistry, National and Kapodistrian University of AthensAbstract Objective G protein-coupled receptor 126 (GPR126) gene has been implicated as a potential susceptibility factor for aggressive periodontitis in Japanese patients. This study aimed to investigate the presence of the GPR126 [c.3086 G > A] (rs536714306) polymorphism in patients with periodontitis in a Greek population and periodontal cases of European ancestry. A total of 82 subjects were recruited: 53 patients periodontally compromised (P) and 29 healthy controls (H). GPR126 genotyping was performed using Sanger sequencing. Additionally, data from the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) consortium were included in this study. Results No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.https://doi.org/10.1186/s13104-025-07443-5PeriodontitisGPR126 genePolymorphism |
| spellingShingle | Eirini Chatzopoulou Galinos Fanourakis Nikolaos Papanikolaou Ioulia Chatzistamou Xanthippi Dereka Heleni Vastardis Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry BMC Research Notes Periodontitis GPR126 gene Polymorphism |
| title | Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry |
| title_full | Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry |
| title_fullStr | Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry |
| title_full_unstemmed | Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry |
| title_short | Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry |
| title_sort | exploring the presence of the gpr126 single nucleotide polymorphism rs536714306 in periodontal patients of european ancestry |
| topic | Periodontitis GPR126 gene Polymorphism |
| url | https://doi.org/10.1186/s13104-025-07443-5 |
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