The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis

The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis

Abstract Acute kidney injury (AKI) is a serious clinical condition whose underlying mechanisms remain unclear. Here we identify a long non-coding RNA, RSDR, as a critical regulator of renal protection in AKI. RSDR interacts with the RNA-binding protein hnRNPK, forming a positive feedback loop that e...

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Main Authors: Bojun Li, Fangyou Lin, Baofeng Song, ShangTing Han, Zehua Ye, Yushi Sun, Peihan Wang, Yuqi Xia, Weimin Yu, Xiangjun Zhou, Fan Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62433-2
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https://doi.org/10.1038/s41467-025-62433-2

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