Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study
Background: Acute kidney injury (AKI) is characterized by a rapid decline in kidney function, resulting in significant morbidity and mortality. This review summarizes our knowledge of AKI risk factors, pathogenesis, prediction, diagnosis, and emerging management approaches. Methods: A comprehensive...
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| Format: | Article |
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Mazandaran University of Medical Sciences and Health Services
2022-11-01
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| Series: | Research in Molecular Medicine |
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| Online Access: | http://rmm.mazums.ac.ir/article-1-484-en.pdf |
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| author | Tamer A. Addissouky Majeed M. A. Ali Ibrahim El Tantawy El Sayed Yuliang Wang Ayman El Baz Naglaa Elarabany Ahmed A. Khalil |
| author_facet | Tamer A. Addissouky Majeed M. A. Ali Ibrahim El Tantawy El Sayed Yuliang Wang Ayman El Baz Naglaa Elarabany Ahmed A. Khalil |
| author_sort | Tamer A. Addissouky |
| collection | DOAJ |
| description | Background: Acute kidney injury (AKI) is characterized by a rapid decline in kidney function, resulting in significant morbidity and mortality. This review summarizes our knowledge of AKI risk factors, pathogenesis, prediction, diagnosis, and emerging management approaches.
Methods: A comprehensive literature search was conducted to summarize current knowledge on AKI. Five electronic databases were searched using various combinations of search terms related to AKI’s risk factors, pathogenesis, prediction, diagnosis, and management approaches. The databases included PubMed, Embase, Web of Science, CINAHL, and Cochrane Central Register of Controlled Trials. Relevant publications were limited to those written in English from 2016 to 2024, but some prior studies were included if highly seminal. Reference lists were also reviewed to find other sources. The full texts of all possibly relevant articles were assessed for inclusion. Data were extracted on study details and findings concerning AKI causes, biomarkers, prediction strategies, diagnostic techniques, treatments, and perspectives to enhance prevention and outcomes. Quality was considered during data extraction, prioritizing well-performed randomized controlled trials, systematic reviews, and large epidemiological studies. Case reports and select editorials were included to summarize specific topics. Extracted data were narratively synthesized to provide an overview of current AKI knowledge and highlight opportunities for mitigating its impact. Through searching multiple databases using applicable index terms, hand searching reference lists, screening and extracting pertinent published literature, this review aims to understand AKI complications and advance solutions from the existing evidence base.
Results: This review summarizes current knowledge on AKI risk mechanisms, diagnostic approaches, emerging therapies and implications of personalized medicine leveraging multi-omics for optimizing prediction and precision treatment.
Conclusion: Despite progress, AKI has remained challenging. However, integrative approaches leveraging new technologies offer hope for improving AKI prevention and management. |
| format | Article |
| id | doaj-art-bbe44b7852c342e2bac9ea6e6a5b2971 |
| institution | OA Journals |
| issn | 2322-1348 2322-133X |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Mazandaran University of Medical Sciences and Health Services |
| record_format | Article |
| series | Research in Molecular Medicine |
| spelling | doaj-art-bbe44b7852c342e2bac9ea6e6a5b29712025-08-20T02:14:35ZengMazandaran University of Medical Sciences and Health ServicesResearch in Molecular Medicine2322-13482322-133X2022-11-01104193204Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review StudyTamer A. Addissouky0Majeed M. A. Ali1Ibrahim El Tantawy El Sayed2Yuliang Wang3Ayman El Baz4Naglaa Elarabany5Ahmed A. Khalil6 Department of Medical Laboratories, Al-Hadi University College, Baghdad, Iraq Department of Medical Laboratories, Al-Hadi University College, Baghdad, Iraq Department of Biochemistry, Faculty of Science, Menoufia University, Menoufia, Egypt School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China Department of Basic Medical Sciences, Faculty of Medicine, Ibn Sina University for Medical Sciences, Amman, Jordan Department of Biology, Sajir College of Arts and Science, Shaqra University, Shaqra, Saudi Arabia Department of Pathology, Baystate Medical Center, Springfield, United States Background: Acute kidney injury (AKI) is characterized by a rapid decline in kidney function, resulting in significant morbidity and mortality. This review summarizes our knowledge of AKI risk factors, pathogenesis, prediction, diagnosis, and emerging management approaches. Methods: A comprehensive literature search was conducted to summarize current knowledge on AKI. Five electronic databases were searched using various combinations of search terms related to AKI’s risk factors, pathogenesis, prediction, diagnosis, and management approaches. The databases included PubMed, Embase, Web of Science, CINAHL, and Cochrane Central Register of Controlled Trials. Relevant publications were limited to those written in English from 2016 to 2024, but some prior studies were included if highly seminal. Reference lists were also reviewed to find other sources. The full texts of all possibly relevant articles were assessed for inclusion. Data were extracted on study details and findings concerning AKI causes, biomarkers, prediction strategies, diagnostic techniques, treatments, and perspectives to enhance prevention and outcomes. Quality was considered during data extraction, prioritizing well-performed randomized controlled trials, systematic reviews, and large epidemiological studies. Case reports and select editorials were included to summarize specific topics. Extracted data were narratively synthesized to provide an overview of current AKI knowledge and highlight opportunities for mitigating its impact. Through searching multiple databases using applicable index terms, hand searching reference lists, screening and extracting pertinent published literature, this review aims to understand AKI complications and advance solutions from the existing evidence base. Results: This review summarizes current knowledge on AKI risk mechanisms, diagnostic approaches, emerging therapies and implications of personalized medicine leveraging multi-omics for optimizing prediction and precision treatment. Conclusion: Despite progress, AKI has remained challenging. However, integrative approaches leveraging new technologies offer hope for improving AKI prevention and management.http://rmm.mazums.ac.ir/article-1-484-en.pdfacute kidney injuryimaging modalitiesbiomarker panelsnanotechnologytraditional medicinesartificial intelligence |
| spellingShingle | Tamer A. Addissouky Majeed M. A. Ali Ibrahim El Tantawy El Sayed Yuliang Wang Ayman El Baz Naglaa Elarabany Ahmed A. Khalil Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study Research in Molecular Medicine acute kidney injury imaging modalities biomarker panels nanotechnology traditional medicines artificial intelligence |
| title | Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study |
| title_full | Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study |
| title_fullStr | Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study |
| title_full_unstemmed | Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study |
| title_short | Risk Factors, Etiology, Pathology, and Diagnostic Methods for Acute Kidney Injury: A Review Study |
| title_sort | risk factors etiology pathology and diagnostic methods for acute kidney injury a review study |
| topic | acute kidney injury imaging modalities biomarker panels nanotechnology traditional medicines artificial intelligence |
| url | http://rmm.mazums.ac.ir/article-1-484-en.pdf |
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