ACT001 Suppresses the Malignant Progression of Small‐Cell Lung Cancer by Inhibiting Lactate Production and Promoting Anti‐Tumor Immunity

ACT001 Suppresses the Malignant Progression of Small‐Cell Lung Cancer by Inhibiting Lactate Production and Promoting Anti‐Tumor Immunity

ABSTRACT Background Improving the “cold” tumor immune microenvironment (TIME) of small‐cell lung cancer (SCLC) represents a promising therapeutic approach. The metabolite lactate plays a crucial role in shaping the immune‐cold tumor microenvironment (TME) and facilitating tumor progression. Phosphog...

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Bibliographic Details
Main Authors: Xiao‐Jing Ding, Ting Mei, Xiao‐Nan Xi, Jing‐Ya Wang, Wen‐Jing Wang, Yue Chen, Ya‐Xin Lu, Ting‐Ting Qin, Ding‐Zhi Huang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Thoracic Cancer
Subjects:
ACT001
aerobic glycolysis
lactate
PGK1
small‐cell lung cancer
tumor associated macrophages
Online Access:https://doi.org/10.1111/1759-7714.70028
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