Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.

Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.

Exposure to lower-than-therapeutic levels of anti-tuberculosis drugs is likely to cause selection of resistant strains of Mycobacterium tuberculosis and treatment failure. The first-line anti-tuberculosis (TB) regimen consists of rifampicin, isoniazid, pyrazinamide, and ethambutol, and correct manag...

Full description

Saved in:

Bibliographic Details
Main Authors:	Paolo Denti, Kidola Jeremiah, Emmanuel Chigutsa, Daniel Faurholt-Jepsen, George PrayGod, Nyagosya Range, Sandra Castel, Lubbe Wiesner, Christian Munch Hagen, Michael Christiansen, John Changalucha, Helen McIlleron, Henrik Friis, Aase Bengaard Andersen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0141002
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The association of Schistosoma and geohelminth infections with β-cell function and insulin resistance among HIV-infected and HIV-uninfected adults: A cross-sectional study in Tanzania.
by: George PrayGod, et al.
Published: (2022-01-01)

Levels and correlates of physical activity and capacity among HIV-infected compared to HIV-uninfected individuals.
by: Brenda Kitilya, et al.
Published: (2022-01-01)

Influence of hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency on diagnosis of diabetes by HbA1c among Tanzanian adults with and without HIV: A cross-sectional study.
by: Belinda Kweka, et al.
Published: (2020-01-01)

Indoor Air Pollution and Delayed Measles Vaccination Increase the Risk of Severe Pneumonia in Children: Results from a Case-Control Study in Mwanza, Tanzania.
by: George PrayGod, et al.
Published: (2016-01-01)

Bifidobacterium adolescentis is resistant to pyrazinamide, isoniazid, and streptomycin
by: Anagha Nellikka, et al.
Published: (2024-11-01)

The association between indoor biofuel use for cooking and glucose metabolism in adults: A cross-sectional study in Tanzania.
by: Happyness Kunzi, et al.
Published: (2025-01-01)

Association of environmental enteropathy with prediabetes and diabetes: A cross-sectional study among Tanzanian adults
by: George PrayGod, et al.
Published: (2025-01-01)

Comparison of Pyrazinamide with Isoniazid for Their Effects on the Heme Biosynthetic Pathway in Mouse Liver
by: Fu-Ying Qin, et al.
Published: (2025-05-01)

Pyrazinamide-Induced Hibernoma
by: Pankaj Das, et al.
Published: (2024-10-01)

Analysis of Isoniazid, Streptomycin and Ethambutol resistance in Mycobacterium tuberculosis isolates from Morocco
by: Imane Chaoui, et al.
Published: (2009-05-01)

Associations between dietary patterns and intestinal inflammation among HIV-infected and uninfected adults: A cross-sectional study in Tanzania
by: Evangelista Kenan Malindisa, et al.
Published: (2024-01-01)

Hypersensitivity Reaction and Tolerance Induction to Ethambutol
by: Josefina Rodrigues Cernadas, et al.
Published: (2013-01-01)

Development and characterisation of lyophilised ethambutol-loaded polymeric nanoparticles
by: Eknath Kole, et al.
Published: (2025-04-01)

Mycobacterium Tuberculosis Persister Cell Formation after Pyrazinamide Exposure
by: Shuqi Wang, et al.
Published: (2024-08-01)

Clinical profile and visual outcomes in ethambutol-induced toxic optic neuropathy
by: Jenil Sheth, et al.
Published: (2025-06-01)

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis.
by: Michael G Whitfield, et al.
Published: (2015-01-01)

The role of Technetium-99m-Ethambutol scintigraphy in the management of spinal tuberculosis
by: Lisa Herawati Diah, et al.
Published: (2019-01-01)

The role of 99mTc-ethambutol scintigraphy to diagnose pulmonary tuberculosis
by: Prayudi Santoso, et al.
Published: (2022-01-01)

Dissecting regional variability in Pyrazinamide prescribing practices for tuberculosis treatment in Japan
by: Nobuaki Kobayashi, et al.
Published: (2024-12-01)

Pyrazinamide-Induced Exfoliative Dermatitis in a Patient on Hemodialysis: A Rare Complication
by: Krishnaswamy Jaisuresh
Published: (2013-01-01)

PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
by: V. A. Serebryakova, et al.
Published: (2014-07-01)

Hepatic safety of pretomanid- and pyrazinamide-containing regimens in TB Alliance clinical trials
by: J. Nedelman, et al.
Published: (2025-08-01)

Pyrazinamide resistance, Mycobacterium tuberculosis lineage and treatment outcomes in San Francisco, California.
by: Jonathan M Budzik, et al.
Published: (2014-01-01)

Phenotypic and genotypic characterization of Mycobacterium tuberculosis pyrazinamide resistance—India, 2018–2020
by: Sembulingam Tamilzhalagan, et al.
Published: (2025-01-01)

Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride
by: M. Mathrusri Annapurna, et al.
Published: (2006-01-01)

STUDY OF SOME PATHOLOGICAL CHANGES IN MICE GROUPS INDUCED BY MYCOBACTERIUM TUBERCULOSIS AND TREATED WITH ETHAMBUTOL
by: Suhair H. Al-kutbi
Published: (2010-12-01)

Thermodynamic and Structural Characterization of a Mechanochemically Synthesized Pyrazinamide–Acetylsalicylic–Acid Eutectic Mixture
by: Luís H. S. Queiroz, et al.
Published: (2025-02-01)

Analysis of gene expression in patients prior to TB treatment to identify those associated with pyrazinamide-hepatotoxicity
by: N. Zielinski, et al.
Published: (2025-08-01)

Temporal evolution and factors influencing visual function and RNFL thickness in ethambutol-associated optic neuropathy
by: Taimin Guo, et al.
Published: (2025-04-01)

Disseminated Pyrazinamide-Resistant Mycobacterium Bovis in an AIDS Patient: The Role of Molecular Diagnosis and Optimized Therapy
by: Fang Y, et al.
Published: (2025-05-01)

Frequency of mutational changes in the embB among the ethambutol-resistant strains of Mycobacterium tuberculosis in Iran
by: Faranak Rezaei, et al.
Published: (2016-04-01)

Correction: Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis.
by: Edgar A Florentini, et al.
Published: (2021-01-01)

A prospective study on the effect of ethambutol on retinal nerve fiber layer thickness and central macular thickness
by: Sanchari Sarkar, et al.
Published: (2025-07-01)

Comprehensive evaluation of the MeltPro MTB/PZA assay for prediction of pyrazinamide resistance in multidrug-resistant tuberculosis
by: Guiqing He, et al.
Published: (2025-07-01)

Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis from sputum samples
by: Emily Toscano-Guerra, et al.
Published: (2024-12-01)

Quality Evaluation of Ethambutol Hydrochloride Tablet Batches Available in Governmental Health Facilities of Jimma Town, Southwest Ethiopia
by: Meseret Yirdaw, et al.
Published: (2021-01-01)

The implications of mutations in multiple genes associated with ethambutol resistance among multidrug-resistant tuberculosis isolates from China
by: Ma-chao Li, et al.
Published: (2025-03-01)

Pyrazinamide Resistance: A Major Cause of Switching Shorter to Longer Bedaquiline-based Regimens in Multidrug-resistant Tuberculosis Patients
by: Oki Nugraha Putra, et al.
Published: (2024-12-01)

Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis.
by: Lufina Tsirizani Galileya, et al.
Published: (2023-11-01)

Rapid diagnosis of drug resistance to fluoroquinolones, amikacin, capreomycin, kanamycin and ethambutol using genotype MTBDRsl assay: a meta-analysis.
by: Yan Feng, et al.
Published: (2013-01-01)