The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications
Pulmonary fibrosis (PF) is a fatal disease characterized by progressive fibrosis of lung tissue, with a key pathological feature of excessive accumulation of extracellular matrix. PF occurs from complicated origins, while emerging findings have suggested the involvement of the environmental factors...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1647300/full |
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| author | Jingru Huang Jianfeng Qin Yuguang Zhu Ao Shen |
| author_facet | Jingru Huang Jianfeng Qin Yuguang Zhu Ao Shen |
| author_sort | Jingru Huang |
| collection | DOAJ |
| description | Pulmonary fibrosis (PF) is a fatal disease characterized by progressive fibrosis of lung tissue, with a key pathological feature of excessive accumulation of extracellular matrix. PF occurs from complicated origins, while emerging findings have suggested the involvement of the environmental factors in the risk of PF through epigenetic regulation. This article will discuss how recent advances in epigenetic alterations of DNA methylation, RNA methylation, histone modifications, and non-coding RNAs contribute to PF development through molecular mechanisms and cellular processes, including fibroblast-to-myofibroblast transition (FMT), epithelial-to-mesenchymal transition (EMT), alveolar epithelial cell injury and immune cell interactions in the past 5 years. |
| format | Article |
| id | doaj-art-bbd8b60210ce466aa1941397d4a24bdf |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-bbd8b60210ce466aa1941397d4a24bdf2025-08-20T03:50:53ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-07-011210.3389/fmolb.2025.16473001647300The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implicationsJingru HuangJianfeng QinYuguang ZhuAo ShenPulmonary fibrosis (PF) is a fatal disease characterized by progressive fibrosis of lung tissue, with a key pathological feature of excessive accumulation of extracellular matrix. PF occurs from complicated origins, while emerging findings have suggested the involvement of the environmental factors in the risk of PF through epigenetic regulation. This article will discuss how recent advances in epigenetic alterations of DNA methylation, RNA methylation, histone modifications, and non-coding RNAs contribute to PF development through molecular mechanisms and cellular processes, including fibroblast-to-myofibroblast transition (FMT), epithelial-to-mesenchymal transition (EMT), alveolar epithelial cell injury and immune cell interactions in the past 5 years.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1647300/fullidiopathic pulmonary fibrosisepigenetic regulationDNA methylationRNA methylationhistone modificationsnon-coding RNA |
| spellingShingle | Jingru Huang Jianfeng Qin Yuguang Zhu Ao Shen The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications Frontiers in Molecular Biosciences idiopathic pulmonary fibrosis epigenetic regulation DNA methylation RNA methylation histone modifications non-coding RNA |
| title | The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications |
| title_full | The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications |
| title_fullStr | The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications |
| title_full_unstemmed | The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications |
| title_short | The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications |
| title_sort | role of epigenetics in pulmonary fibrosis recent advances in mechanistic insights and therapeutic implications |
| topic | idiopathic pulmonary fibrosis epigenetic regulation DNA methylation RNA methylation histone modifications non-coding RNA |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1647300/full |
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