Extracellular vesicles: new horizons in neurodegeneration
Summary: Extracellular vesicles (EVs) are lipid-enclosed nanovesicles secreted by diverse cell types that orchestrate intercellular communication through cargo delivery. Their pivotal roles span from supporting the development of normal central nervous system (CNS) to contributing to the pathogenesi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396425000490 |
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| _version_ | 1850236356244013056 |
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| author | Jun Chen Chen Tian Xiao Xiong Ying Yang Jing Zhang |
| author_facet | Jun Chen Chen Tian Xiao Xiong Ying Yang Jing Zhang |
| author_sort | Jun Chen |
| collection | DOAJ |
| description | Summary: Extracellular vesicles (EVs) are lipid-enclosed nanovesicles secreted by diverse cell types that orchestrate intercellular communication through cargo delivery. Their pivotal roles span from supporting the development of normal central nervous system (CNS) to contributing to the pathogenesis of neurological diseases. Particularly noteworthy is their involvement in the propagation of pathogenic proteins, such as those involved in neurodegenerative disorders, and nucleic acids, closely linking them to disease onset and progression. Moreover, EVs have emerged as promising diagnostic biomarkers for neurological disorders and as tools for disease staging, owing to their ability to traverse the blood-brain barrier and their specific, stable, and accessible properties. This review comprehensively explores the realm of CNS-derived EVs found in peripheral blood, encompassing their detection methods, transport mechanisms, and diverse roles in various neurodegenerative diseases. Furthermore, we evaluate the potentials and limitations of EVs in clinical applications and highlight prospective research directions in this rapidly evolving field. |
| format | Article |
| id | doaj-art-bbd7e040551a4d0e95536b5d9fca4cc2 |
| institution | OA Journals |
| issn | 2352-3964 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-bbd7e040551a4d0e95536b5d9fca4cc22025-08-20T02:01:58ZengElsevierEBioMedicine2352-39642025-03-0111310560510.1016/j.ebiom.2025.105605Extracellular vesicles: new horizons in neurodegenerationJun Chen0Chen Tian1Xiao Xiong2Ying Yang3Jing Zhang4Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, ChinaDepartment of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China; Corresponding author.Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China; National Human Brain Bank for Health and Disease, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China; Corresponding author. Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China.Summary: Extracellular vesicles (EVs) are lipid-enclosed nanovesicles secreted by diverse cell types that orchestrate intercellular communication through cargo delivery. Their pivotal roles span from supporting the development of normal central nervous system (CNS) to contributing to the pathogenesis of neurological diseases. Particularly noteworthy is their involvement in the propagation of pathogenic proteins, such as those involved in neurodegenerative disorders, and nucleic acids, closely linking them to disease onset and progression. Moreover, EVs have emerged as promising diagnostic biomarkers for neurological disorders and as tools for disease staging, owing to their ability to traverse the blood-brain barrier and their specific, stable, and accessible properties. This review comprehensively explores the realm of CNS-derived EVs found in peripheral blood, encompassing their detection methods, transport mechanisms, and diverse roles in various neurodegenerative diseases. Furthermore, we evaluate the potentials and limitations of EVs in clinical applications and highlight prospective research directions in this rapidly evolving field.http://www.sciencedirect.com/science/article/pii/S2352396425000490Extracellular vesiclesAlzheimer's diseaseParkinson's diseaseBiomarker |
| spellingShingle | Jun Chen Chen Tian Xiao Xiong Ying Yang Jing Zhang Extracellular vesicles: new horizons in neurodegeneration EBioMedicine Extracellular vesicles Alzheimer's disease Parkinson's disease Biomarker |
| title | Extracellular vesicles: new horizons in neurodegeneration |
| title_full | Extracellular vesicles: new horizons in neurodegeneration |
| title_fullStr | Extracellular vesicles: new horizons in neurodegeneration |
| title_full_unstemmed | Extracellular vesicles: new horizons in neurodegeneration |
| title_short | Extracellular vesicles: new horizons in neurodegeneration |
| title_sort | extracellular vesicles new horizons in neurodegeneration |
| topic | Extracellular vesicles Alzheimer's disease Parkinson's disease Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2352396425000490 |
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