ctDNA-based liquid biopsy reveals wider mutational profile with therapy resistance and metastasis susceptibility signatures in early-stage breast cancer patients

ctDNA-based liquid biopsy reveals wider mutational profile with therapy resistance and metastasis susceptibility signatures in early-stage breast cancer patients

A minimally invasive analysis of plasma cell-free DNA (cfDNA) offers a genomic profiling of early-stage breast cancer (EBC), potentially identifying mutational signatures linked to metastasis and therapy resistance. In this study, paired plasma and tissue samples from 40 hormone receptor-positive (H...

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Main Authors: Atul Bharde, Snigdha Nadagouda, Manoj Dongare, Kanchan Hariramani, Madhura Basavalingegowda, Sumit Haldar, Alain D'Souza, Bhagwat Jadhav, Sangeeta Prajapati, Vikas Jadhav, Sujit Joshi, Aravindan Vasudevan, Mohan Uttarwar, Wenhui Zhou, Sirish Kishore, Kumar Prabhash, Jayant Khandare, Gowhar Shafi
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:The Journal of Liquid Biopsy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950195424001504
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