N-acetyl cysteine through modulation of HDAC2 and GCN5 in the hippocampus mitigates behavioral disorders in the first and second generations of socially isolated mice

N-acetyl cysteine through modulation of HDAC2 and GCN5 in the hippocampus mitigates behavioral disorders in the first and second generations of socially isolated mice

Objective(s): Social isolation stress (SIS) in early life can lead to behavioral disorders. N-acetylcysteine (NAC), an antioxidant, may aid treatment. This study explored NAC's impact on behavior in first and second-generation mice after SIS, focusing on HDAC2 and GCN5 expression in the hippoca...

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Bibliographic Details
Main Authors: Najmeh Asgharzadeh, Ali Noori Diziche, Hossein Amini-Khoei, Nasrin Yazdanpanahi, Mehrdad Shahrani Korrani
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:IBRO Neuroscience Reports
Subjects:
Open field
CA1
CA3
Morris water maze
Forced swimming
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125000144
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