Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D
Vitamin D deficiency has been associated with both type 2 diabetes mellitus (T2DM) and autoimmune disorders. The association of vitamin D with T2DM and thyroid autoimmunity (TAI) has not been investigated. Thus, we aimed to explore the putative association between T2DM and thyroid autoimmunity (TAI)...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/710363 |
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| author | Konstantinos Toulis Xanthippi Tsekmekidou Evangelos Potolidis Triantafyllos Didangelos Anna Gotzamani-Psarrakou Pantelis Zebekakis Michael Daniilidis John Yovos Kalliopi Kotsa |
| author_facet | Konstantinos Toulis Xanthippi Tsekmekidou Evangelos Potolidis Triantafyllos Didangelos Anna Gotzamani-Psarrakou Pantelis Zebekakis Michael Daniilidis John Yovos Kalliopi Kotsa |
| author_sort | Konstantinos Toulis |
| collection | DOAJ |
| description | Vitamin D deficiency has been associated with both type 2 diabetes mellitus (T2DM) and autoimmune disorders. The association of vitamin D with T2DM and thyroid autoimmunity (TAI) has not been investigated. Thus, we aimed to explore the putative association between T2DM and thyroid autoimmunity (TAI) focusing on the role of 25-hydroxy-vitamin D (25(OH)D). Study population included 264 T2DM patients and 234 controls. To explore the potential association between 25(OH)D and thyroid autoimmunity while controlling for potential confounders—namely, age, gender, body mass index, and presence of T2DM—multivariate logistic regression analyses were undertaken. Patients with T2DM were younger (P<0.001) and had significantly lower 25(OH)D levels (P<0.001) and higher anti-TPO titers (P=0.005). Multivariable logistic regression analyses suggested that T2DM and 25(OH)D levels were significantly associated with the presence of thyroid autoimmunity. In an elderly population of diabetic patients and controls with a high prevalence of vitamin D deficiency/insufficiency, a patient with T2DM was found to be 2.5 times more likely to have thyroid autoimmunity compared to a nondiabetic individual and the higher the serum 25(OH)D levels were, the higher this chance was. |
| format | Article |
| id | doaj-art-bbd57f60ecc3472484365727be0af481 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-bbd57f60ecc3472484365727be0af4812025-02-03T06:12:38ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/710363710363Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin DKonstantinos Toulis0Xanthippi Tsekmekidou1Evangelos Potolidis2Triantafyllos Didangelos3Anna Gotzamani-Psarrakou4Pantelis Zebekakis5Michael Daniilidis6John Yovos7Kalliopi Kotsa8Diabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, GreeceDiabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, GreeceDiabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, GreeceFirst Propaedeutic Department of Internal Medicine, AHEPA University Hospital, 54636 Thessaloniki, GreeceLaboratory of Nuclear Medicine, AHEPA University Hospital, 54636 Thessaloniki, GreeceDiabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, GreeceFirst Department of Medicine, AHEPA University Hospital, 54636 Thessaloniki, GreeceDiabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, GreeceDiabetes Center, Department of Endocrinology and Metabolism, AHEPA University Hospital, 54636 Thessaloniki, GreeceVitamin D deficiency has been associated with both type 2 diabetes mellitus (T2DM) and autoimmune disorders. The association of vitamin D with T2DM and thyroid autoimmunity (TAI) has not been investigated. Thus, we aimed to explore the putative association between T2DM and thyroid autoimmunity (TAI) focusing on the role of 25-hydroxy-vitamin D (25(OH)D). Study population included 264 T2DM patients and 234 controls. To explore the potential association between 25(OH)D and thyroid autoimmunity while controlling for potential confounders—namely, age, gender, body mass index, and presence of T2DM—multivariate logistic regression analyses were undertaken. Patients with T2DM were younger (P<0.001) and had significantly lower 25(OH)D levels (P<0.001) and higher anti-TPO titers (P=0.005). Multivariable logistic regression analyses suggested that T2DM and 25(OH)D levels were significantly associated with the presence of thyroid autoimmunity. In an elderly population of diabetic patients and controls with a high prevalence of vitamin D deficiency/insufficiency, a patient with T2DM was found to be 2.5 times more likely to have thyroid autoimmunity compared to a nondiabetic individual and the higher the serum 25(OH)D levels were, the higher this chance was.http://dx.doi.org/10.1155/2015/710363 |
| spellingShingle | Konstantinos Toulis Xanthippi Tsekmekidou Evangelos Potolidis Triantafyllos Didangelos Anna Gotzamani-Psarrakou Pantelis Zebekakis Michael Daniilidis John Yovos Kalliopi Kotsa Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D International Journal of Endocrinology |
| title | Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D |
| title_full | Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D |
| title_fullStr | Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D |
| title_full_unstemmed | Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D |
| title_short | Thyroid Autoimmunity in the Context of Type 2 Diabetes Mellitus: Implications for Vitamin D |
| title_sort | thyroid autoimmunity in the context of type 2 diabetes mellitus implications for vitamin d |
| url | http://dx.doi.org/10.1155/2015/710363 |
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